N. A. Maali, Asmaa Y. Wahman, A. Aly, A. Nassar, M. Douaa, Sayed
{"title":"钐- 5-氟尿嘧啶络合物对人结肠癌细胞系的抗癌活性有显著的诱导作用","authors":"N. A. Maali, Asmaa Y. Wahman, A. Aly, A. Nassar, M. Douaa, Sayed","doi":"10.21608/aunj.2019.221113","DOIUrl":null,"url":null,"abstract":"In the present study samarium 5-fluorouracil (5-FU) complex was prepared to enhance the effectiveness of the 5-FU drug. This complex was characterized by UV/VIS spectrometry high performance liquid chromatography and differential scanning calorimetry. Furthermore, the antitumor effect of the prepared complex was explored on the human colon cancer cell Caco2 via evaluation of the cytotoxic activity of this complex through trypan blue cell viability. Apoptosis was also assessed through morphological changes, by Annexin V=PI flow cytometric analysis. The results revealed that the trivalent Sm enhance the 5-FU effect against the chemo-resistant colorectal carcinoma cell line.","PeriodicalId":8568,"journal":{"name":"Assiut University Journal of Multidisciplinary Scientific Research","volume":"27 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Samarium- 5-fluorouracil complex induces prominently the anticancer activity of human colon cancer cell line\",\"authors\":\"N. A. Maali, Asmaa Y. Wahman, A. Aly, A. Nassar, M. Douaa, Sayed\",\"doi\":\"10.21608/aunj.2019.221113\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the present study samarium 5-fluorouracil (5-FU) complex was prepared to enhance the effectiveness of the 5-FU drug. This complex was characterized by UV/VIS spectrometry high performance liquid chromatography and differential scanning calorimetry. Furthermore, the antitumor effect of the prepared complex was explored on the human colon cancer cell Caco2 via evaluation of the cytotoxic activity of this complex through trypan blue cell viability. Apoptosis was also assessed through morphological changes, by Annexin V=PI flow cytometric analysis. The results revealed that the trivalent Sm enhance the 5-FU effect against the chemo-resistant colorectal carcinoma cell line.\",\"PeriodicalId\":8568,\"journal\":{\"name\":\"Assiut University Journal of Multidisciplinary Scientific Research\",\"volume\":\"27 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Assiut University Journal of Multidisciplinary Scientific Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/aunj.2019.221113\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Assiut University Journal of Multidisciplinary Scientific Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/aunj.2019.221113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Samarium- 5-fluorouracil complex induces prominently the anticancer activity of human colon cancer cell line
In the present study samarium 5-fluorouracil (5-FU) complex was prepared to enhance the effectiveness of the 5-FU drug. This complex was characterized by UV/VIS spectrometry high performance liquid chromatography and differential scanning calorimetry. Furthermore, the antitumor effect of the prepared complex was explored on the human colon cancer cell Caco2 via evaluation of the cytotoxic activity of this complex through trypan blue cell viability. Apoptosis was also assessed through morphological changes, by Annexin V=PI flow cytometric analysis. The results revealed that the trivalent Sm enhance the 5-FU effect against the chemo-resistant colorectal carcinoma cell line.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
