Thomas Hilberath, Remco van Oosten, Juliet Victoria, Hugo Brasselet, Miguel Alcalde, John M. Woodley and Frank Hollmann*,
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引用次数: 0
摘要
本文报道了一种非特异性过加氧酶将环己烷氧化功能化为环己醇/环己酮(ka -油)。使用Agrocybe aegerita的AaeUPO和简单的H2O2作为氧化剂，环己醇浓度超过300 mM (>60%收率)，具有吸引力的生产率(157 mM h-1，约为1)。15 g L-1 h-1)。目前提出的生物氧化系统的局限性已经确定，为未来的改进和实施铺平了道路。
Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
Mol-scale oxyfunctionalization of cyclohexane to cyclohexanol/cyclohexanone (KA-oil) using an unspecific peroxygenase is reported. Using AaeUPO from Agrocybe aegerita and simple H2O2 as an oxidant, cyclohexanol concentrations of more than 300 mM (>60% yield) at attractive productivities (157 mM h–1, approx. 15 g L–1 h–1) were achieved. Current limitations of the proposed biooxidation system have been identified paving the way for future improvements and implementation.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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