导管消融作为室上性心动过速一线治疗的应用不足

Lucas Hollanda Oliveira, M. Viana, C. Luize, Ricardo Sobral de Carvalho, C. Cirenza, Cristiano de Oliveira Dietrich, L. C. Correia, Cláudio Marcelo Bittencourt das Virgens, Juliana Medeiros Filgueiras, M. Barreto, E. Porto, E. Coutinho, Â. de Paola
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Methods and Results The model was derived from a retrospective cohort of patients with SVT or ventricular pre‐excitation referred for CA in a tertiary center. Clinical and demographical features were used as independent variables and non‐referral for CA as first‐line treatment the dependent variable in a stepwise logistic regression analysis. Among 20 clinical‐demographic variables from 350 patients, 10 were included in initial logistic regression analysis: age, women, presence of pre‐excitation on ECG, palpitation, dyspnea and chest discomfort, number of antiarrhythmic drugs before ablation, number of concomitant symptoms, symptoms’ duration and evaluations in the emergency room due to SVT. 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引用次数: 3

摘要

导管消融(CA)是一种安全、有效、经济的技术,可能被认为是治疗症状性室上性心动过速(SVT)的一线策略。尽管有很高的治愈前景,并且国际指南建议将CA作为一线治疗策略,但从诊断到手术的平均时间可能很长。本研究旨在评估与非转诊CA作为SVT患者一线治疗相关的预测因素。方法和结果该模型来源于一个三级中心的室性心动过速或心室预兴奋患者的回顾性队列。在逐步logistic回归分析中,临床和人口统计学特征作为自变量,非转诊CA作为一线治疗的因变量。在来自350例患者的20个临床人口学变量中,有10个变量被纳入了初始logistic回归分析:年龄、女性、ECG上的预兴奋、心悸、呼吸困难和胸部不适、消融前抗心律失常药物的数量、伴随症状的数量、症状持续时间和因SVT在急诊室的评估。经多变量调整分析,年龄(优势比[OR], 1.2;95% ci 1.01-1.32;P=0.04),室上性心动过速时胸部不适(OR, 2.7;可信区间1.6 - -4.7;P<0.001)和消融前抗心律失常药物的数量(OR, 1.8;可信区间1.4 - -2.3;P<0.001)显示非转诊CA作为SVT一线治疗的独立正相关。结论:在我们的logistic回归分析中,不转诊CA作为一线治疗的独立预测因素表明,在转诊过程中,哪些患者将从导管消融中获益最多,在决策过程中存在偏差。它们很可能表明,一个扭曲的医疗决策过程导致导管消融使用不足。
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Underuse of Catheter Ablation as First‐Line Therapy for Supraventricular Tachycardia
Background Catheter ablation (CA) is a safe, effective, cost‐effective technique and may be considered a first‐line strategy for the treatment of symptomatic supraventricular tachycardias (SVT). Despite the high prospect of cure and the recommendations of international guidelines in considering CA as a first‐line treatment strategy, the average time between diagnosis and the procedure may be long. The present study aims to evaluate predictors related to non‐referral for CA as first‐line treatment in patients with SVT. Methods and Results The model was derived from a retrospective cohort of patients with SVT or ventricular pre‐excitation referred for CA in a tertiary center. Clinical and demographical features were used as independent variables and non‐referral for CA as first‐line treatment the dependent variable in a stepwise logistic regression analysis. Among 20 clinical‐demographic variables from 350 patients, 10 were included in initial logistic regression analysis: age, women, presence of pre‐excitation on ECG, palpitation, dyspnea and chest discomfort, number of antiarrhythmic drugs before ablation, number of concomitant symptoms, symptoms’ duration and evaluations in the emergency room due to SVT. After multivariable adjusted analysis, age (odds ratio [OR], 1.2; 95% CI 1.01–1.32; P=0.04), chest discomfort during supraventricular tachycardia (OR, 2.7; CI 1.6–4.7; P<0.001) and number of antiarrhythmic drugs before ablation (OR, 1.8; CI 1.4–2.3; P<0.001) showed a positive independent association for non‐referral for CA as SVT first‐line treatment. Conclusions The independent predictors of non‐referral for CA as first‐line treatment in our logistic regression analysis indicate the existence of biases in the decision‐making process in the referral process of patients who would benefit the most from catheter ablation. They very likely suggest a skewed medical decision‐making process leading to catheter ablation underuse.
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