Phytochemical study and evaluation of the antiulcer effect of aqueous and hydroethanolic extracts of the recipe for the leaves of Eriosema erici-rosenii re fr. and Neoboutonia melleri müll. arg. prain in mice

This work aimed to justify the traditional use of the recipe based on Eriosema erici and Neoboutonia mülleri in the treatment of gastric ulcers. The ulcer was induced by the HCl/ethanol mixture. To elucidate the antiulcer mechanism; the effect of the aqueous (300 and 600 mg/kg) and hydroethanolic (300 and 600 mg/kg) extracts was evaluated on lipid peroxidation, the production of antioxidant enzymes, the release of nitric oxide. At the doses used, the extracts of the recipe significantly reduced gastric lesions. In addition, they showed an antioxidant effect not only by inhibiting the ferric reducing power but also by opposing lipid peroxidation and improving the expression of antioxidant factors by increasing the production of catalase (CAT), glutathiones (GSH; GPx), super oxide dismutase (SOD). This coupled with a nitrogen effect. The phytochemical screening revealed the presence of flavonoids, tannins, terpernoids which could justify the antiulcer and antioxidative effect observed.