{"title":"抗癌无机环-DNA相互作用的拉曼研究","authors":"Michel Manfait, Jean-François Labarre","doi":"10.1016/0378-4487(81)80024-6","DOIUrl":null,"url":null,"abstract":"<div><p>A Raman investigation of pentaziridinocyclodiphosphathiazene -DNA interactions in vitro suggests that the alkylating sites on DNA for this powerful antitumour agent are essentially the oxygen atoms of the ribose backbone with a second order dialkylating effect on the N(7) and <span><math><mtext>N</mtext></math></span>H<sub>2</sub> positions of Adenine. These contrasts with the case of hexaziridinocyclotriphosphazene which interacts with the DNA by the same two routes but through a balanced mode.</p></div>","PeriodicalId":100049,"journal":{"name":"Advances in Molecular Relaxation and Interaction Processes","volume":"21 2","pages":"Pages 117-130"},"PeriodicalIF":0.0000,"publicationDate":"1981-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0378-4487(81)80024-6","citationCount":"8","resultStr":"{\"title\":\"Raman studies on anticancer inorganic ring -DNA interactions\",\"authors\":\"Michel Manfait, Jean-François Labarre\",\"doi\":\"10.1016/0378-4487(81)80024-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A Raman investigation of pentaziridinocyclodiphosphathiazene -DNA interactions in vitro suggests that the alkylating sites on DNA for this powerful antitumour agent are essentially the oxygen atoms of the ribose backbone with a second order dialkylating effect on the N(7) and <span><math><mtext>N</mtext></math></span>H<sub>2</sub> positions of Adenine. These contrasts with the case of hexaziridinocyclotriphosphazene which interacts with the DNA by the same two routes but through a balanced mode.</p></div>\",\"PeriodicalId\":100049,\"journal\":{\"name\":\"Advances in Molecular Relaxation and Interaction Processes\",\"volume\":\"21 2\",\"pages\":\"Pages 117-130\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1981-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0378-4487(81)80024-6\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Molecular Relaxation and Interaction Processes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0378448781800246\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Molecular Relaxation and Interaction Processes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0378448781800246","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Raman studies on anticancer inorganic ring -DNA interactions
A Raman investigation of pentaziridinocyclodiphosphathiazene -DNA interactions in vitro suggests that the alkylating sites on DNA for this powerful antitumour agent are essentially the oxygen atoms of the ribose backbone with a second order dialkylating effect on the N(7) and H2 positions of Adenine. These contrasts with the case of hexaziridinocyclotriphosphazene which interacts with the DNA by the same two routes but through a balanced mode.
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