白细胞介素-8与喉部鳞状细胞癌

M. Grasso, M. Ralli, G. Agolli, M. Fiore, M. Ceccanti, P. Tirassa, M. Vicentiis, A. Greco
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引用次数: 1

摘要

喉鳞状细胞癌(LSCC)是仅次于口腔癌的第二常见的上消化道肿瘤。在过去的二十年中,尽管患者从手术技术、化疗和放疗的最新进展中受益匪浅,但LSCC的生存率并没有显著提高。据报道,细胞因子和生长因子表达的变化与许多癌症的恶性转化有关,包括头颈部鳞状细胞癌和最近的LSCC。据推测,这些细胞因子中的一些可能被用作患者血清中的额外诊断标志物,因为它们在肿瘤细胞中产生过多。这可能具有很大的价值,因为目前还没有可靠的标志物来预测肿瘤的发展或复发。白细胞介素-8 (IL-8)是一种趋化因子(C-X-C基序)配体8 (CXCL8),目前被报道在肿瘤侵袭、血管生成和转移中发挥重要作用。最近的研究表明,LSCC患者IL-8浓度升高,与淋巴结转移和T分型呈正相关。白细胞介素-8水平与较短的总生存期和癌症无进展生存期无显著相关。研究头颈部肿瘤的起源、侵袭和转移机制是头颈部肿瘤,尤其是LSCC的新兴和最有前途的科学领域之一。生物标志物如IL-8可以作为筛选试验,并作为临床决策的支持,为个别患者提供适当的治疗和术后护理。
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Interleukin-8 and laryngeal squamous cell carcinoma
Laryngeal squamous cell carcinoma (LSCC) is the second most common neoplasm of the upper aerodigestive tract after cancer of the oral cavity. Over the past two decades, even though patients have benefited greatly from the latest advances in surgical techniques, chemotherapy and radiation therapy, the survival rate of LSCC has not improved significantly. It is reported that changes in the expression of cytokines and growth factors have implications in the malignant transformation of many cancers including head and neck squamous cell carcinoma and, more recently, LSCC. It has been hypothesized that some of these cytokines may be used as additional diagnostic markers in the sera of patients because of their excessive production by the tumor cells. This could be of great value since there are currently no reliable markers to predict either tumor development or relapse. Interleukin-8 (IL-8), a chemokine (C-X-C motif) ligand 8 (CXCL8), is now reported to play an important role in cancer invasion, angiogenesis and metastasis. Recent studies have shown an increased concentration of IL-8 in patients with LSCC and a positive association with lymph node metastasis and T classification. Interleukin-8 levels were not significantly associated with shorter overall survival and cancer progression-free survival. The investigation of the mechanisms of origin, invasion, and metastasis of the cancer is one of the emergent and most promising scientific fields in head and neck cancer, especially in LSCC. Biomarkers such as IL-8 could have a role as a screening test and as a support of the clinical decisions for appropriate therapy and postoperative care in individual patients.
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