在世卫组织非洲区域儿童疫苗接种规划中引入第二剂含麻疹疫苗——吸取的经验教训

B. Masresha, R. Luce, J. Okeibunor, Messeret Shibeshi, R. Kamadjeu, A. Fall
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引用次数: 19

摘要

世卫组织建议所有国家将第二剂含麻疹疫苗(MCV2)纳入其国家常规疫苗接种计划,无论第一剂含麻疹疫苗(MCV1)的覆盖水平如何。截至2016年12月,非洲区域已有26个国家引入了MCV2。方法我们回顾了世卫组织和联合国儿童基金会在这些国家对MCV1和MCV2的覆盖率估计,以及来自11个国家的MCV2引入后评估报告。结果23个国家有世卫组织/联合国儿童基金会估计的2015年MCV2覆盖率。其中,2个国家的MCV1和MCV2疫苗覆盖率均≥95%,5个国家的两剂疫苗覆盖率均> 80%。12个国家的MCV1 - MCV2辍学率超过20%。2012年至2015年在11个国家开展的MCV2引入后评估显示,卫生工作者培训不足、家长的致敏和认识培养不足以及剂量记录不理想做法是导致这些国家MCV2覆盖率低的常见规划弱点。结论:在大多数国家,MCV2的覆盖率仍然很低,这反映在较高的辍学率上。要持续实现区域消除麻疹目标,有必要提高麻疹v2疫苗的覆盖率。国家免疫规划必须根据扩大免疫方案规划可获得的标准介绍和评价指南,改进MCV2的实施。
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Introduction of the Second Dose of Measles Containing Vaccine in the Childhood Vaccination Programs Within the WHO Africa Region – Lessons Learnt
Background WHO recommends all countries to include a second routine dose of measles containing vaccine (MCV2) in their national routine vaccination schedules regardless of the level of coverage with the first routine dose of measles containing vaccine (MCV1). As of Dec 2016, 26 countries in the African Region have introduced MCV2. Methods We reviewed the WHO UNICEF coverage estimates for MCV1 and MCV2 in these countries, and the reports of the post introduction evaluation of MCV2 from 11 countries. Results Twenty three countries have WHO/UNICEF estimates of MCV2 coverage available in 2015. Of these, 2 countries have coverage of ≥ 95% for both MCV1 and MCV2 while 5 countries have coverage of > 80% for both doses. Dropout rates of >20% MCV1 – MCV2 exist in 12 countries. Post-MCV2 introduction evaluations done in 11 countries from 2012 to 2015 showed that inadequate health worker training, insufficient sensitization and awareness generation among parents and suboptimal dose recording practices were common programmatic weaknesses that contributed to the low MCV2 coverage in these countries. Conclusion MCV2 coverage remains low as reflected in large drop-out rates in most countries. Higher MCV2 coverage is necessary to sustainably achieve the regional measles elimination goal. National immunization programs must improve implementation of MCV2 using the standard introduction and evaluation guidelines available for EPI program planning.
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