抗糖尿病药物临床前筛选模型的新范例:探究复杂的方法和进展

Keval Y. Raval, Yash Dhamsaniya
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摘要

动物模型在糖尿病研究中起着至关重要的作用,有助于理解1型和2型糖尿病的发病机制和评估潜在的治疗干预措施。这些模型具有许多优点,包括诱导稳定高血糖和高脂血症的能力,最小的可变性,以及研究基因突变和单基因效应的机会。然而,它们也存在局限性,如诱导期长、葡萄糖参数波动、对其他器官的潜在毒性以及成本高。各种筛选模型,包括体外试验和模型,如四氧嘧啶诱导和链脲佐菌素诱导的糖尿病,是研究糖尿病和测试药物疗效的宝贵工具。选择合适的模型需要仔细考虑具体的研究目标。尽管存在局限性,但动物模型对于促进我们对糖尿病的了解和开发有效的治疗方法仍然是不可或缺的。
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Emerging paradigms in pre-clinical screening models for drugs acting against diabetes: Delving into complex approaches and advancements
Animal models play a critical role in diabetes research, aiding in the comprehension of both type 1 and type 2 diabetes pathogenesis and the assessment of potential therapeutic interventions. These models offer numerous advantages, including the ability to induce stable hyperglycemia and hyperlipidemia, minimal variability, and the opportunity to study genetic mutations and single gene effects. However, they also present limitations such as lengthy induction periods, fluctuating glucose parameters, potential toxicity to other organs, and high costs. Various screening models, encompassing in vitro assays and models like Alloxan-induced and Streptozotocin-induced diabetes, serve as valuable tools for investigating diabetes and testing drug efficacy. The selection of an appropriate model requires careful consideration of specific research objectives. Despite their limitations, animal models continue to be indispensable for advancing our understanding of diabetes and developing effective treatments.
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