人体鼻腔内气流和固体颗粒传输的数学模型

P. Trusov, N. Zaitseva, M. Tsinker, A. Nekrasova
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引用次数: 1

摘要

作为人体呼吸系统数学模型的一部分,考虑了一个子模型,用于研究固体颗粒(悬浮颗粒物(PM) /粉尘颗粒)的非稳态气流和不同大小的颗粒在人体鼻腔中的沉积。假设鼻腔被骨-软骨隔膜分成两个对称的部分(相对于鼻中隔);考虑了人鼻腔右侧的平均几何形状。吸入的空气被认为是均匀的单组分气体和固体粉尘颗粒的多相混合物。采用欧拉-拉格朗日方法来模拟多相混合物的运动:用粘性液体模型来描述载气相的运动;所携带的相(粉尘颗粒)被建模为不同大小的独立夹杂物。吸入空气因与墙壁接触而加热的过程也被考虑在内。利用Ansys CFX软件对不同工况下多相空气与粉尘的非定常流场特征进行了分析。已经注意到,在研究鼻腔气流时,需要考虑湍流的存在,因此建议使用k-ω模型。得到了吸入空气在鼻腔内的速度场;给出不同时间点鼻腔温度分布;估算吸入空气不同温度下的空气加热量;根据实际机械制造生产的颗粒大小,对鼻腔中沉积颗粒的比例进行估计;给出悬浮粒子的运动轨迹。由此可见,超过99.7%的直径大于10微米的颗粒沉积在人的鼻腔中;随着颗粒直径和质量的减小,沉积颗粒的比例减小。粒径小于2.5微米的悬浮颗粒几乎不会在鼻腔内沉积。它们可以随着吸入的空气深入人的下呼吸道和肺部,具有纤维化和毒性作用,可引起疾病。所得到的结果与其他科学家进行的个别研究的结果完全一致。该模型的进一步发展涉及研究人体肺部的气流,并模拟因吸入进入人体的环境因素(包括粉尘颗粒)的有害影响而引起的疾病的形成。
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Mathematical Model of Airflow and Solid Particles Transport in The Human Nasal Cavity
As part of the mathematical model of the human respiratory system, a submodel is considered for the study of the non-steady airflow with solid particles (suspended particulate matter (PM) / dust particles) and the deposition of particles of various sizes in the human nasal cavity. It is assumed that the nasal cavity is divided by the bone-cartilaginous septum into two symmetrical (relative to the nasal septum) parts; the average geometry of the right part of the human nasal cavity is considered. The inhaled air is considered as a multiphase mixture of homogeneous single-component gas and solid dust particles. The Eulerian-Lagrangian approach to modeling the motion of a multiphase mixture is used: a viscous liquid model is used to describe the motion of the carrier gas phase; the carried phase (dust particles) is modeled as separate inclusions of various sizes. The process of heating the inhaled air due to its contact with the walls is also taken into account. The features of the unsteady flow of a multiphase air mixture with dust particles were obtained using Ansys CFX for several scenarios. It has been noted that when studying the airflow in the nasal cavity, it is necessary to take into account the presence of turbulence, for which it is proposed to use the k-ω model. The velocity fields of inhaled air in the nasal cavity have been obtained; presented temperature distributions in the nasal cavity at different time points; made estimates of air heating at different temperatures of inhaled air; gave estimates of the proportion of deposited particles in the nasal cavity depending on the particle size for real machine-building production; presented trajectories of movement of suspended particles. Thus, it is shown that more than 99.7 % of particles with a diameter of more than 10 microns deposit in the human nasal cavity; as the particle diameter and mass decrease, the proportion of deposited particles decreases. Suspended particles with a size of less than 2.5 microns almost do not deposit in the nasal cavity. They can penetrate deeper into the lower airways and lungs of a person with the inhaled air and, having fibrogenic and toxic effect, can cause diseases. The results obtained are in good agreement with the results of individual studies performed by other scientists. Further development of the model involves studying airflow in the human lungs and modeling the formation of diseases caused by the harmful effects of environmental factors (including dust particles) entering the human body by inhalation.
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来源期刊
Mathematical Biology and Bioinformatics
Mathematical Biology and Bioinformatics Mathematics-Applied Mathematics
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1.10
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13
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