BioSig: an informatics framework for representing the physiological responses of living cells

Subcellular experimental datasets and detailed cell models are required before modeling of whole organs. Cell modeling requires repeated interaction between simulation and experimental data. This review describes a coupled system of informatics and instrument control suitable for extracting information at the subcellular level. The BioSig informatics framework annotates time-series images with experimental variables and computed representation such as physiological responses, whereas visual servoing optical microscopy (VSOM) is used for adaptive perturbation and interaction with living cells.