Sirtuins Regulation In Diabetic Condition

Sirtuins are NAD+ dependent enzymes having an ability to modify the structures of proteins and alter their functions by deacetylation activity. This property of sirtuins gave them much attention since past few years and their importance is growing in research rapidly among various multidisciplinary areas. Sirtuins regulate various diseases including diabetes, aging, heart failure and other metabolic disorders which results in growing interest of researchers in understanding the biology of these wonder molecules around the globe. In general, these are the protein deacetylases and weak mono ADP ribosyltransferases which action various histones and transcription factors [1]. Sirtuins are considered as a switch that controls protein acetylation/deacetylation states and ultimately regulates various factors involved in different disease conditions associated with energy metabolism, aging and oxidative stress. Initially, most of the sirtuin research revolved around cancer biology but with time their importance is also unveiled in other disease conditions including diabetes.