{"title":"作为潜在抗hiv药物的新型3 '，5 ' -同环核苷酸的合成","authors":"M. Drew, S. Gorsuch, Jayne H. M. Gould, J. Mann","doi":"10.1039/A900800D","DOIUrl":null,"url":null,"abstract":"(5S)-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H)-one has been converted into cytosine 2′,3′-dideoxy-3′,5′-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"26 1","pages":"969-978"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"The synthesis of novel 3′,5′-homocyclic nucleotides as potential anti-HIV agents\",\"authors\":\"M. Drew, S. Gorsuch, Jayne H. M. Gould, J. Mann\",\"doi\":\"10.1039/A900800D\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"(5S)-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H)-one has been converted into cytosine 2′,3′-dideoxy-3′,5′-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.\",\"PeriodicalId\":17267,\"journal\":{\"name\":\"Journal of The Chemical Society-perkin Transactions 1\",\"volume\":\"26 1\",\"pages\":\"969-978\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-06-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Chemical Society-perkin Transactions 1\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/A900800D\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Chemical Society-perkin Transactions 1","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/A900800D","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The synthesis of novel 3′,5′-homocyclic nucleotides as potential anti-HIV agents
(5S)-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H)-one has been converted into cytosine 2′,3′-dideoxy-3′,5′-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.
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