天然肽类抗生素在人关节软骨和滑膜中的表达

Clinical Diagnostic Laboratory Immunology Pub Date : 2001-09-01 DOI:10.1128/CDLI.8.5.1021-1023.2001

F. Paulsen, T. Pufe, W. Petersen, B. Tillmann

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引用次数: 26

摘要

摘要:鉴于目前在肢体关节上频繁使用侵入性手术，令人惊讶的是，关节炎症是一种罕见的事件。我们质疑抗菌肽是否在保护人类关节软骨和滑膜免受炎症因子的影响中发挥作用。我们的结果暗示了防御素在保护人类关节免受病原体侵害的作用。

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Expression of Natural Peptide Antibiotics in Human Articular Cartilage and Synovial Membrane

ABSTRACT In view of frequent present use of invasive procedures on limb joints, it is astonishing that articular joint inflammation is a rare event. We questioned whether antimicrobial peptides play a role in protecting human articular cartilage and synovial membrane against inflammatory agents. Our results implicate defensins in the protection of human articular joints against pathogens.

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Clinical Diagnostic Laboratory Immunology

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