{"title":"磷酸二酯酶作为肿瘤化疗的新靶点","authors":"G. Sandeep, S. Bhasker, Y. Ranganath","doi":"10.5580/2c8","DOIUrl":null,"url":null,"abstract":"The Phosphodiesterase inhibitors have been used for the treatment of non-malignant conditions like asthma, pulmonary hypertension and erectile dysfunction etc, but the recent research suggests that they have great therapeutic value in the adjunctive therapy of Cancer. This article reviews the various substances elevating the intracellular cyclic AMP levels such as cAMP analogues and Phosphodiesterases inhibitors to induce apoptosis selectively in a variety of cancer cell lines with out affecting the normal cells. Their usefulness in the adjunctive therapy of cancer is explained.","PeriodicalId":22523,"journal":{"name":"The Internet Journal of Pharmacology","volume":"10 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Phosphodiesterase as a novel target in Cancer Chemotherapy\",\"authors\":\"G. Sandeep, S. Bhasker, Y. Ranganath\",\"doi\":\"10.5580/2c8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The Phosphodiesterase inhibitors have been used for the treatment of non-malignant conditions like asthma, pulmonary hypertension and erectile dysfunction etc, but the recent research suggests that they have great therapeutic value in the adjunctive therapy of Cancer. This article reviews the various substances elevating the intracellular cyclic AMP levels such as cAMP analogues and Phosphodiesterases inhibitors to induce apoptosis selectively in a variety of cancer cell lines with out affecting the normal cells. Their usefulness in the adjunctive therapy of cancer is explained.\",\"PeriodicalId\":22523,\"journal\":{\"name\":\"The Internet Journal of Pharmacology\",\"volume\":\"10 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/2c8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/2c8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Phosphodiesterase as a novel target in Cancer Chemotherapy
The Phosphodiesterase inhibitors have been used for the treatment of non-malignant conditions like asthma, pulmonary hypertension and erectile dysfunction etc, but the recent research suggests that they have great therapeutic value in the adjunctive therapy of Cancer. This article reviews the various substances elevating the intracellular cyclic AMP levels such as cAMP analogues and Phosphodiesterases inhibitors to induce apoptosis selectively in a variety of cancer cell lines with out affecting the normal cells. Their usefulness in the adjunctive therapy of cancer is explained.
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