海棠叶甲醇提取物中植物化学物质的光谱分析及ADME预测

Sachin Vanpure, Nishant Nandkhile, R. Bhondwe, Suresh Palve
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引用次数: 1

摘要

植物化学物质是在植物中发现的具有生物活性的化合物。药用植物的植物化学物质可以治疗多种疾病,因此植物的植物化学筛选是发现和开发治疗剂的必要条件。在目前的研究中。粗提物的FTIR光谱证实了其存在烷烃、羧酸、醇、芳烃和酯类。甲醇提取物在254nm处有11个峰,可能为酚类和醇类化合物。采用紫外-可见分光光度计对提取液进行扫描,在200 ~ 700nm范围内分别检测不同吸收度的特征峰。ADME研究特别关注亲脂性、水溶性、药代动力学、药物相似性、药物化学等重要性质,本研究使用名为Swiss ADME的insilico ADME工具进行。
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Spectroscopic Analysis and ADME prediction of Phytochemicals in Methanolic Leaves Extract of Avicennia marina
Phytochemicals are biologically active compounds found in plants. Phytochemicals of medicinal plant can cure various diseases thus phytochemical screening of plants is necessary for the discovery and devlopment of therapeutic agents. In present study. The FTIR spectrum of crude extract confirmed the presence of alkanes, carboxylic acid, alcohol, aromatics and esters. The HPLC analysis of methanolic extract shows 11 peaks at 254nm, it may be phenolic and alcoholic compounds. The plant extract was scanned by using UV-VIS spectrophotometer ranging from 200-700nm and characteristic peaks were detected with different absorption respectively. The ADME study particularly focuses on important properties like lipophilicity, water solubility, pharmacokinetic, drug likeness, medicinal chemistry and this study carried out by using insilico ADME tool called Swiss ADME.
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