海洋来源的生物活性甾体化合物作为潜在的细胞毒性药物对各种癌细胞系

N. Sisir, Ankita Sharma
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引用次数: 0

摘要

为了开发自然动植物的潜力,迫切需要研究和解开隐藏在我们巨大的自然多样性中的全部化学奥秘。自然资源包括不同气候带的大片森林和海岸。海洋覆盖了地球表面的71%。尽管如此,陆地上的物种数量远高于海洋。世界上大约16%的物种生活在海洋中,80%生活在陆地上,其余的生活在淡水中。非常需要扩大这些海域的能力,以保持全球相关性。需要进行更深入的研究,特别是对深海天然产物的研究,以巩固海洋生物对未来药物发现的潜力的研究。从海洋生物中发现了许多潜在的药物和先导化合物。本研究试图总结目前海洋来源的生物活性类固醇化合物作为潜在的细胞毒性药物。
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Marine Sourced Bioactive Steroidal Compounds as Potential Cytotoxic Agents against Various Cancer Cell Lines
To exploit the potential of the natural flora and fauna, it is urgent to study and unravel full chemical mysteries hidden in our vast natural diversity. Natural resources consist of large forest areas in diverse climatic zones, and also of the sea coast. Ocean covers 71% of the earth surface. Inspite of that, number of species on land is much higher than the oceans. About 16% of world’s species lives in oceans, 80% on land and remaining lives in fresh water. There is a great need to expand the capabilities in these sea areas to remain globally relevant. More in-depth study, especially on deep-sea natural products, needs to be carried out to solidify the research on the potential for marine organisms to contribute to the future of drug discovery. Many potential drugs and lead compounds are discovered from the marine organisms. The present study is an attempt to summarize current marine sourced bioactive steroidal compounds as potential cytotoxic agents.
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