Y. Wen, Zhi-feng Zhang, Ning-ning Liu, Yu-hong Xiang, Zhuo-yong Zhang, G. Andrei, R. Snoeck, D. Schols, Qingshan Zhang, Qin-pei Wu
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Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides
ABSTRACT A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity.
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