合理设计多肽疫苗和COVID-19肆虐的生物信息学方案

A. Nandy, S. Basak, S. Manna
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摘要

目前正在进行的冠状病毒大流行SARSCOV-2,可互换称为COVID-19感染,在短时间内改变了几乎所有人类的生活方式。它的影响如此强烈,以至于所有的人类活动都以这样或那样的方式停止了相当长的一段时间,导致了无数的生命损失和经济流失,以至于人们公开辩论世界是否会永远改变我们习惯的方式[1]。就像在几个流行的情况困扰人类社会在这个21世纪,如严重急性呼吸系统综合症冠状病毒(冠)从2002年到2003年[2],中东的呼吸系统综合症冠状病毒(MERS-CoV) 2012[3],并在2009年H1N1流感[4],这个时候没有药物或疫苗可用SARS-CoV-2,但是考虑到其影响的努力在全世界有超过100的实验室开发疫苗以极大的紧迫感。
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A Bioinformatics Protocol for Rational Design of Peptide Vaccines and the COVID-19 Rampage
The currently ongoing coronavirus pandemic, the SARSCOV-2, interchangeably referred to as the COVID-19 infection, has in a short span of time altered the ways and means of almost all of mankind. So strong has been its effect that all human activity ceased in one way or another for a considerable time, led to significant loss of life and economic drain of untold proportions such that there are open debates on whether the world will forever now change from the way we were used to [1]. Just like in the case of the several epidemics that have plagued human society in this 21st century, such as severe acute respiratory syndrome coronavirus (SARS-CoV) from 2002 to 2003 [2], the Middle East respiratory syndrome coronavirus (MERS-CoV) of 2012 [3], and H1N1 influenza in 2009 [4], there are no drugs or vaccines available at this time for the SARS-CoV-2, but considering its impact efforts are under way in more than 100 labs worldwide to develop a vaccine with great urgency.
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