阿尔茨海默病及其目前的治疗方法;有治愈的可能吗?

Ammar Ehab, Mohamed Izham Mohamed Ibrahim, Marel Magdi, Mohamed Ayman, N. Zidan, Abdelbaset Osman, S. Ashraf, Mayar Mohamed, Mirna Magdy, Marina Hany, Marise Adly, Nourhan Kamel, Amr Maher, Ammar Yaser, Yara Ahmed, Amal Abdelkarim, Marehan Ehab, Rana Wael, R. Hathout
{"title":"阿尔茨海默病及其目前的治疗方法;有治愈的可能吗?","authors":"Ammar Ehab, Mohamed Izham Mohamed Ibrahim, Marel Magdi, Mohamed Ayman, N. Zidan, Abdelbaset Osman, S. Ashraf, Mayar Mohamed, Mirna Magdy, Marina Hany, Marise Adly, Nourhan Kamel, Amr Maher, Ammar Yaser, Yara Ahmed, Amal Abdelkarim, Marehan Ehab, Rana Wael, R. Hathout","doi":"10.17352/OJC.000012","DOIUrl":null,"url":null,"abstract":"Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that slowly destroys the memory and the thinking skills, and eventually the ability to carry out the simplest tasks. This has motivated lots of scientists to search for an ultimate treatment or cure for this serious disease. There are various causes & risk factors which cause AD and are the reasons for its progression. The drugs used in AD are usually a combination between different classes but never those of the same class such as Acetyl cholinesterase inhibitors which increase the availability of acetylcholine & NMDA receptors antagonists such as memantine. Most of the currently used drugs are mainly used to treat the symptoms, but lately some drugs have shown some promise in both treating & curing AD such as Aducanumab which is in the final phases of the clinical trials that resulted in the clearing of Amyloid plaques affecting cells communication. Since there are newly discovered causes of the disease, there are various other approaches in dealing with AD which will be discussed thoroughly in this review article.","PeriodicalId":19563,"journal":{"name":"Open journal of physical chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Alzheimer’s disease and its current treatments; Is there a possibility for a cure?\",\"authors\":\"Ammar Ehab, Mohamed Izham Mohamed Ibrahim, Marel Magdi, Mohamed Ayman, N. Zidan, Abdelbaset Osman, S. Ashraf, Mayar Mohamed, Mirna Magdy, Marina Hany, Marise Adly, Nourhan Kamel, Amr Maher, Ammar Yaser, Yara Ahmed, Amal Abdelkarim, Marehan Ehab, Rana Wael, R. Hathout\",\"doi\":\"10.17352/OJC.000012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that slowly destroys the memory and the thinking skills, and eventually the ability to carry out the simplest tasks. This has motivated lots of scientists to search for an ultimate treatment or cure for this serious disease. There are various causes & risk factors which cause AD and are the reasons for its progression. The drugs used in AD are usually a combination between different classes but never those of the same class such as Acetyl cholinesterase inhibitors which increase the availability of acetylcholine & NMDA receptors antagonists such as memantine. Most of the currently used drugs are mainly used to treat the symptoms, but lately some drugs have shown some promise in both treating & curing AD such as Aducanumab which is in the final phases of the clinical trials that resulted in the clearing of Amyloid plaques affecting cells communication. Since there are newly discovered causes of the disease, there are various other approaches in dealing with AD which will be discussed thoroughly in this review article.\",\"PeriodicalId\":19563,\"journal\":{\"name\":\"Open journal of physical chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-06-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open journal of physical chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17352/OJC.000012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open journal of physical chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17352/OJC.000012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4

摘要

阿尔茨海默病(AD)是一种不可逆的、进行性的大脑疾病,它会慢慢地破坏记忆和思维能力,并最终破坏执行最简单任务的能力。这促使许多科学家寻找这种严重疾病的最终治疗或治愈方法。引起AD的原因和危险因素多种多样,也是其发展的原因。用于阿尔茨海默病的药物通常是不同类别的药物组合,而不是同一类别的药物,如乙酰胆碱酯酶抑制剂,它增加了乙酰胆碱和NMDA受体拮抗剂的可用性,如美金刚。目前使用的大多数药物主要用于治疗症状,但最近一些药物在治疗和治愈AD方面显示出一些希望,例如Aducanumab,该药物处于临床试验的最后阶段,可清除影响细胞通讯的淀粉样斑块。由于有新发现的疾病的原因,还有各种其他的方法来处理AD,这将在这篇综述文章中进行深入的讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Alzheimer’s disease and its current treatments; Is there a possibility for a cure?
Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that slowly destroys the memory and the thinking skills, and eventually the ability to carry out the simplest tasks. This has motivated lots of scientists to search for an ultimate treatment or cure for this serious disease. There are various causes & risk factors which cause AD and are the reasons for its progression. The drugs used in AD are usually a combination between different classes but never those of the same class such as Acetyl cholinesterase inhibitors which increase the availability of acetylcholine & NMDA receptors antagonists such as memantine. Most of the currently used drugs are mainly used to treat the symptoms, but lately some drugs have shown some promise in both treating & curing AD such as Aducanumab which is in the final phases of the clinical trials that resulted in the clearing of Amyloid plaques affecting cells communication. Since there are newly discovered causes of the disease, there are various other approaches in dealing with AD which will be discussed thoroughly in this review article.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Reprocessable Non-Isocyanate Polyurethane Vitrimers Optical spectroscopic analysis, supercapacitance, photocatalysis of BaTixFe12-(4/3)xO19 hexagonal nanoparticles Reclamation of wastewater polluted with antihypertensive drug residues by the biological+solar-photocatalytic sequential treatment plant Antioxidant activity assay and determination of phenolic and flavonoid content of Libho (Ficus Septica Burm. F) fruits Synthesis of optically pure calix[4]arenes derived from Evans oxazolidinone and/or pyranose
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1