{"title":"2-呋喃基苯并咪唑在McF-7细胞系中抗血管生成抑制vegf的晶体结构","authors":"Keith J. Flanagan, Y. Shaker, Ahmed Temirak","doi":"10.3987/COM-15-13258","DOIUrl":null,"url":null,"abstract":"The first crystal structures of four 2-furylbenzimidazole acetohydrazide derivatives are reported herein. The compounds have been shown to be planar with a small cant that varies from 4 to 30°. The X-ray crystal structure of the compounds 7-10 revealed that compounds are oriented in the cis configuration which suggests that the acid hydrazide group is essential for the enhanced potency of 2-furylbenzimidazoles as anti-angiogenic agents.","PeriodicalId":12850,"journal":{"name":"Heterocycles : an international journal for reviews and communications in heterocyclic chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"CRYSTAL STRUCTURES OF 2-FURYLBENZIMIDAZOLES WITH ANTIANGIOGENIC INHIBITION OF VEGF IN CELL LINE MCF-7\",\"authors\":\"Keith J. Flanagan, Y. Shaker, Ahmed Temirak\",\"doi\":\"10.3987/COM-15-13258\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The first crystal structures of four 2-furylbenzimidazole acetohydrazide derivatives are reported herein. The compounds have been shown to be planar with a small cant that varies from 4 to 30°. The X-ray crystal structure of the compounds 7-10 revealed that compounds are oriented in the cis configuration which suggests that the acid hydrazide group is essential for the enhanced potency of 2-furylbenzimidazoles as anti-angiogenic agents.\",\"PeriodicalId\":12850,\"journal\":{\"name\":\"Heterocycles : an international journal for reviews and communications in heterocyclic chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Heterocycles : an international journal for reviews and communications in heterocyclic chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3987/COM-15-13258\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heterocycles : an international journal for reviews and communications in heterocyclic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3987/COM-15-13258","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CRYSTAL STRUCTURES OF 2-FURYLBENZIMIDAZOLES WITH ANTIANGIOGENIC INHIBITION OF VEGF IN CELL LINE MCF-7
The first crystal structures of four 2-furylbenzimidazole acetohydrazide derivatives are reported herein. The compounds have been shown to be planar with a small cant that varies from 4 to 30°. The X-ray crystal structure of the compounds 7-10 revealed that compounds are oriented in the cis configuration which suggests that the acid hydrazide group is essential for the enhanced potency of 2-furylbenzimidazoles as anti-angiogenic agents.
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