蛇毒蛋白酶Agkisacutacin在实验模型中的抗血栓和溶栓活性

Shaoping Li , H Ji , X Cheng , Banjamin X.Y Li , T.B Ng
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引用次数: 19

摘要

研究了从尖蝮蛇(Agkistrodon acutus)中分离得到的Agkisacutacin (Agk)体外和体内抗血栓和溶栓活性。采用的模型有钱德勒模型、动静脉分流模型和肺栓塞模型。同时观察了Agkisacutacin对胶原、二磷酸腺苷(adenosine diphosphate, ADP)和凝血酶诱导的凝血、血浆纤维蛋白原和血小板聚集的影响。结果表明,阿基苏他星能明显抑制钱德勒模型和动静脉分流模型大鼠血栓形成,加速肺栓塞的溶栓。这些数据表明阿基舒他星具有抗血栓和溶栓活性。Agkisacutacin也被部分表征。
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Antithrombotic and thrombolytic activities of Agkisacutacin, a snake venom proteinase, in experimental models

The antithrombotic and thrombolytic activities of Agkisacutacin (Agk), a component isolated from Agkistrodon acutus, were determined in vitro and in vivo. The models employed included Chandler's model, arterio-venous shunt model and pulmonary embolus model. The effects of Agkisacutacin on coagulation, plasma fibrinogen and platelet aggregation induced by collagen, adenosine diphosphate (ADP) and thrombin were also investigated. The results showed that Agkisacutacin can significantly inhibit thrombus formation in Chandler's and arterio-venous shunt models, and accelerate thrombolysis of pulmonary emboli in rats. The data suggested that Agkisacutacin possessed antithrombotic and thrombolytic activities. Agkisacutacin was also partial characterized.

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