埃塞俄比亚西北部贡达尔大学医院尿路病原菌患病率和抗生素耐药性的变化趋势

M. Tiruneh, Sisay Yifru, Mucheye Gizachew, K. Molla, Yeshambel Belyhun, F. Moges, Mengistu Endris
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引用次数: 25

摘要

背景。在发展中国家的大多数医院,由于缺乏培养设施,尿路感染的治疗是经验性的。这导致了多重耐药尿路病原体的出现。培养和药敏试验对指导治疗至关重要。目标。在为期两年的研究期间,评估尿路病原体对常用抗生素的变化患病率和耐药模式。方法。收集尿液标本并进行培养。采用标准方法鉴定尿路病原菌并进行抗生素耐药性检测。数据分析采用SPSS 16版统计软件。P值< 0.05为差异有统计学意义。结果。在过去和现在的研究中,最常见的分离株是大肠杆菌、克雷伯氏菌、con、金黄色葡萄球菌、变形杆菌和柠檬酸杆菌。以前分离的肠杆菌科菌株对环丙沙星的敏感性为100%,而目前分离的菌株对环丙沙星的耐药性为31%至60%。以前的分离株对庆大霉素的耐药性较低。本研究以多耐药菌株为主。结论。大肠杆菌在两个研究阶段均占优势。目前的分离株比以前的更耐药。以前的一些分离株对环丙沙星100%敏感,而现在的分离株越来越耐药。环丙沙星和庆大霉素已被推荐用于尿路感染的经验性治疗。
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Changing Trends in Prevalence and Antibiotics Resistance of Uropathogens in Patients Attending the Gondar University Hospital, Northwest Ethiopia
Background. In most hospitals of developing countries, urinary tract infections are treated empirically because of lack of culture facilities. This leads to emergence of multiresistant uropathogens. Culturing and drug susceptibility testing are essential to guide therapy. Objectives. To assess changing prevalence and resistance pattern of uropathogens to commonly used antibiotics in a two-year study period. Methods. Urine specimens were collected and cultured. Uropathogens were identified by standard methods and tested for antibiotics resistance. Data were analyzed using SPSS version 16 statistical sofware. P value < 0.05 was considered statistically significant. Results. The commonest isolates in both the previous and present studies were E. coli, Klebsiella, CoNS, S. aureus, Proteus, and Citrobacter species. Previous isolates of Enterobacteriaceae were 100% sensitive to ciprofloxacin, whereas present isolates developed 31% to 60% resistance to it. Previous isolates were less resistant to gentamycin than the present ones. Multiresistance isolates were predominant in present study than previous ones. Conclusion. E. coli was predominant in the two study periods. Present isolates were more resistant than previous ones. Some previous isolates were 100% sensitive to ciprofloxacin, whereas present isolates were increasingly resistant. Ciprofloxacin and gentamicin have been recommended for empiric treatment of urinary tract infections.
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