用sLORETA电生理神经显像比较22例年龄匹配的男女精神分裂症患者。

A. Eugene, J. Masiak, J. Kapica, M. Masiak, R. Weinshilboum
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引用次数: 7

摘要

本电生理神经成像研究的目的是对奥氮平和利培酮的药效学与性别的关系提供更深层次的机制理解。在此过程中,我们对22名男性和女性进行了年龄匹配,并评估了他们的静息状态脑电图记录,随后使用标准的低分辨率脑电断层扫描来观察两组患者大脑活动的差异。方法分析精神分裂症患者在精神科接受非典型抗精神病药物奥氮平或利培酮治疗期间的脑电图数据。22名男性和女性年龄匹配,分析19个Ag/AgCl电极的脑电图记录。采用标准低分辨率电磁断层扫描(sLORETA)对30秒静息脑电图进行频谱转换。最后计算了sLORETA全球场强在各波段的三维统计非参数图。结果与男性相比,女性精神分裂症患者位于额叶中回背外侧前额皮质慢波δ频的神经元同步性明显增加(t= -2.881, p < 0.03580)。这些发现表明,与同龄男性相比,女性经历了更多的多巴胺(D2)受体和血清素(5-HT2)受体神经元阻断。此外,我们的发现为第二代抗精神病药物奥氮平和利培酮的药效学提供了见解。结论与男性相比,女性精神分裂症患者D2和5-HT2受体比同龄男性精神分裂症患者更容易被阻断。在临床上,这可能意味着与男性患者相比,女性患者的治疗反应时间更快。
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Electrophysiological Neuroimaging using sLORETA Comparing 22 Age Matched Male and Female Schizophrenia Patients.
INTRODUCTION The purpose of this electrophysiological neuroimaging study was to provide a deeper mechanistic understanding of both olanzapine and risperidone pharmacodynamics relative to gender. In doing so, we age-matched 22 men and women and evaluated their resting-state EEG recordings and later used standard low resolution brain Electrotomography to visualize the differences in brain activity amongst the two patient groups. METHODS In this investigation, electroencephalogram (EEG) data were analyzed from male and female schizophrenia patients treated with either olanzapine or risperidone, both atypical antipsychotics, during their in-patient stay at the Department of Psychiatry. Twenty-two males and females were age-matched and EEG recordings were analyzed from 19 Ag/AgCl electrodes. Thirty-seconds of resting EEG were spectrally transformed in standardized low resolution electromagnetic tomography (sLORETA). 3D statistical non-paramentric maps for the sLORETA Global Field Power within each band were finally computed. RESULTS The results indicated that, relative to males patients, females schizophrenia patients had increased neuronal synchronization in delta frequency, slow-wave, EEG band located in the dorsolateral prefrontal cortex, within the middle frontal gyrus (t= -2.881, p < 0.03580). These findings suggest that females experience greater dopamine (D2) receptor and serotonin (5-HT2) receptor neuronal blockade relative to age-matched males. Further, our finding provided insight to the pharmacodynamics of second-generation antipsychotics olanzapine and risperidone. CONCLUSION When compared to male patients, female patients, suffering from schizophrenia, have D2 and 5-HT2 receptors that are blocked more readily than age-matched male schizophrenia patients. Clinically, this may translate into a quicker time to treatment-response in females as compared to male patients.
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