Antibacterial potentials of pillar[5]arene, pillar[4]arene[1]quinone derivative and their isatin inclusion complexes

ABSTRACT Host–guest complexation of decamethoxypillar[5]arene and difunctionalized pillar[4]arene[1]quinone with isatin were demonstrated by 1H NMR titration experiments. The antibacterial potentials of isatin, decamethoxypillar[5]arene, difunctionalized pillar[4]arene[1]quinone and their isatin inclusion complexes were evaluated against both Gram-positive and Gram-negative bacteria by the well-diffusion method. The results of the antibacterial assay revealed that decamethoxypillar[5]arene displayed very good antibacterial activity than the difunctionalized pillar[4]arene[1]quinone. Isatin inclusion complex of decamethoxypillar[5]arene showed very good antibacterial activity as that of chloramphenicol with S. aureus, P. aeruginosa, K. pneumoniae and E. coli. Checkerboard assay revealed synergic effects of P[5]A and isatin combinations against selected microorganisms. In silico toxicity predictions suggested the potential of isatin, decamethoxypillar[5]arene and the difunctionalized pillar[4]arene[1]quinone as prospective drug candidates. Graphical abstract Isatin inclusion complex of decamethoxy pillar[5]arene showed very good antibacterial activity as that of chloramphenicol with S. aureus, P. aeruginosa, K. pneumoniae and E. coli.