Prise en charge des suspicions d’allergies aux antibiotiques

The suspicions of antibiotic allergies are extremely frequent. True demonstrated allergies are less frequent. If urticarias and maculo-papular eruptions are amongst the most frequent clinical presentations, clinical forms are numerous and severe anaphylaxis, severe toxidermia and/or organ involvements exist and are lifethreatening. Simple avoidance could be risky as well. A firm diagnosis is important because most of the suspicions are not confirmed. The precise description of the clinical history is mandatory. This diagnosis is based on immediate and late-reading skin tests and provocation tests, in the absence of contra-indications. These tests require special training and could be at risk, therefore expertise in the field is needed as well as following up the guidelines edited by the European Network for Drug Allergy - EAACI.