非st段抬高急性冠状动脉综合征患者阻塞性冠状动脉扩张的新预测指标:血浆粥样硬化指数

U. Küçük, K. Arslan
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引用次数: 0

摘要

简介:冠状动脉扩张(CAE)是一种罕见的心血管疾病,临床范围从无症状到心肌梗死。动脉粥样硬化在CAE的发病机制中起关键作用。最近,已经确定血浆动脉粥样硬化指数(AIP)是动脉粥样硬化的一个强有力的预测指标。本研究的目的是探讨非st段抬高急性冠脉综合征(NSTE-ACS)患者的阻塞性CAE和AIP之间是否存在关系。材料和方法:本研究对医院电子病历进行回顾性分析。研究共纳入213例NSTE-ACS患者。根据非梗阻性和梗阻性CAE分为两组。比较各组间AIP值,并通过回归分析评估AIP值是否可作为预测阻塞性CAE发生风险的指标。结果:与非梗阻性CAE组相比,梗阻性CAE组AIP值具有数值和统计学意义。多因素logistic回归分析发现AIP是NSTE-ACS患者梗阻性CAE的预测因子,在受试者工作曲线分析中,AIP值0.33以上预测NSTE-ACS患者梗阻性CAE的敏感性为90%,特异性为68%。结论:NSTE-ACS患者存在阻塞性CAE时AIP值升高。我们的研究结果提示AIP可能参与梗阻性CAE的发病机制。
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A New Predictor of Obstructive Coronary Artery Ectasia in Patients with Non-ST-Elevation Acute Coronary Syndrome: The Atherogenic Index of Plasma
Introduction: Coronary artery ectasia (CAE) is one of the uncommon cardiovascular disorders with a clinical spectrum ranging from asymptomatic cases to myocardial infarction. Atherosclerosis plays a pivotal role in the pathogenesis of CAE. Recently, it has been determined that the atherogenic index of plasma (AIP) is a strong predictive marker for atherosclerosis. The aim of this study was to investigate whether there is a relationship between obstructive CAE and AIP in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS). Materials and methods: In this retrospective study, hospital electronic patient records were retrospectively examined. A total of 213 NSTE-ACS patients were included in the study. Patients were divided into two groups according to non-obstructive and obstructive CAE. The AIP value was compared between groups and regression analysis evaluated whether it is an indicator to predict the risk of obstructive CAE. Results: The AIP value was found to be numerically and statistically significant in the obstructive CAE group compared to the non-obstructive CAE group. The multivariate logistic regression analysis identified AIP as a predictor of obstructive CAE in NSTE-ACS patients in the receiver operating curve analysis, AIP values above 0.33 had 90% sensitivity and 68% specificity to predict obstructive CAE in NSTE-ACS patients. Conclusions: AIP values were increased in the presence of obstructive CAE in NSTE-ACS patients. Our findings suggest that AIP may be involved in the pathogenesis of obstructive CAE.
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