外用凝胶的概述

Mina J. Jabbar, W. Ali
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引用次数: 0

摘要

近年来,凝胶由于其无油脂、易于涂抹和易于拆卸等良好特性,已优先用于化妆品和局部药物制剂。然而,它面临的一个障碍是无法包裹疏水化合物。因此,研究人员开发了一种新的方法,通过将凝胶与乳液混合来绕过这一限制,从而产生了一种新的局部药物输送系统,称为乳液。乳凝胶既保留了凝胶的所有优点,又提供了药物的双重释放,可以有效地控制外用后药物的释放和吸收。乳液的制备需要连贯的步骤,这包括乳液和凝胶的制备以及确定它们的混合比例。最后,对制备的凝胶进行评价,以确保其局部应用的适宜性和有效性。
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An overview of emulgels for topical application
In recent years, gels have been preferentially used for cosmetics and topical pharmaceutical preparations due to their favorable characteristics, such as being greaseless, readily spreadable and easily removable. However, one obstacle that faced it was the inability to enclose hydrophobic compounds. Therefore, a novel approach was developed to circumvent this limitation by mixing the gel with an emulsion, which led to creation of a new topical drug delivery system known as emulgel. Emulgel preserves all favorable features of gel and provides also dual release for drug, thus can be utilized effectively in controlling release and absorption of medication after topical application. Emulgel preparation requires coherent steps, this includes preparation of emulsion and gel and determining their mixing ratio. Finally, the prepared emulgels should be evaluated to ensure their suitability and efficacy for the topical application.
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