New Nanometal-Containing Hepatoprotectors: Obtaining and Studying Biological Properties

Abstract The article is devoted to the study of the biological properties of nanocomposites obtained by immobilisation of precious metals (Au2+, Ag2+) in the structures of extracts of plant hepatoprotectors (milk thistle, saffron), in experiments on small sexually mature laboratory animals. Aqueous solutions of nanocomposites were administered to animals intraperitoneally 30 minutes prior to exposure to ionising radiation. Quantitative changes in lipid peroxidation were determined on the basis of the analysis of the concentration of malonic dealdehyde and hydroperoxide in liver tissue of control and experimental animals. It was revealed that nanocomposites introduced to animals before irradiation partially protect them from its destructive effect. More pronounced hepatoprotective effects in comparison with Ag2+ ions are manifested by Au2+ ions. Animals were also tested for behavioural responses in an open field model against the background of the introduction of a corresponding dose of the nanocomposite solution before irradiation. There were also changes in behavioural responses.