双水杨醛乙二胺席夫碱及其类镧配合物的抗菌活性

Mahmud, S.D., Birnin-Yauri, U.A., Liman, M.G., Manga, S.B.
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引用次数: 0

摘要

希夫碱极易与金属离子形成配合物,特别是过渡金属的配合物已广泛应用于包括抗菌治疗在内的许多人类领域。然而,镧系-希夫碱配合物作为抗菌剂的潜力尚未得到充分的研究。本研究旨在合成双水杨醛乙二胺希夫碱及其类镧(III)配合物并测定其抗菌活性。以水杨醛和乙二胺为原料,在乙醇回流条件下合成了希夫碱的镝(III)、钆(III)、钕(III)和钐(III)配合物,并用圆盘扩散法测定了它们的抗菌活性。双水杨醛乙二胺为亮晶晶黄色,产率为93%;配合物为淡黄色至深黄色,产率为94 ~ 98%。双水杨醛乙二胺对白念珠菌(32mm, 100mg/ml)、黑曲霉(20mm, 100mg/ml)和镰刀菌(17mm, 100mg/ml)具有良好的抑菌活性,但其配合物对所有真菌的抑菌活性均较低(07-11mm, 100mg/ml)或无活性(06mm, 100mg/ml)。双水杨醛乙二胺对大肠杆菌(100mg/ml时为8mm)、假单胞菌(100mg/ml时为6mm)和克雷伯菌(100mg/ml时为13mm)的抑菌活性均低于氨苄氯(17 ~ 20mm),其8 ~ 14mm的类镧(III)配合物(100mg/ml时为8 ~ 14mm)的抑菌活性均高于双水杨醛乙二胺,但类镧(III)配合物活性仍低于氨苄氯。考虑到双水杨醛乙二胺及其类镧(III)配合物对细菌和真菌分离物的体外抑菌活性,两者都不是潜在的抗菌药物,但双水杨醛乙二胺可能是潜在的抗菌药物。因此,我们建议进一步研究,以探索其抗真菌治疗的全部潜力。
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Antimicrobial activity of Bis-salicylaldehyde Ethylenediamine Schiff Base and Its Lanthanoids (III) Complexes
Schiff base readily form complex with metal ions and the resultant complexes especially from transition metals were extensively used in many fields of human endeavor including antimicrobial therapy. However, the potentials of Lanthanide-Schiff base complexes as an antimicrobial agent have not been adequately studied. This study aims to synthesize and determine the antimicrobial activity of Bis-salicylaldehyde ethylenediamine Schiff Base and its Lanthanoids (III) Complexes. The Dysprosium (III), Gadolinium (III), Neodymium (III) and Samarium (III) complexes of Schiff base derived from Salicylaldehyde and ethylenediamine were synthesized under reflux condition in ethanol and their antimicrobial activity were determined using disc diffusion method. Bis-salicylaldehyde ethylenediamine was a shiny crystalline yellow with a yield of 93% and its complexes were various sheds of yellow ranges from pale to dark, with percentage yield between 94-98%. The Bis-salicylaldehyde ethylenediamine had good activity against C. albican (32mm at 100mg/ml), A. niger (20mm at 100mg/ml) and Fusarium Spp (17mm at 100mg/ml) but its complexes had low (07-11mm at 100mg/ml) or no (06mm at 100mg/ml) activity against all the fungal isolates. The antibacterial activity of the Bis-salicylaldehyde ethylenediamine against E. coli (8mm at 100mg/ml), Pseudomonas (6mm at 100mg/ml) and Klebsiella (13mm at 100mg/ml) was lower than that of Ampiclox (between 17 to 20mm) and even though, all its Lanthanoid (III) complexes between 8 to 14mm at 100mg/ml) had higher antibacterial activity than the Bis-salicylaldehydeethylenediamine but still the activity of Lanthanoid (III) complexes was lower than that of Ampiclox. Considering the in-vitro antimicrobial activity exhibited by Bis-salicylaldehyde ethylenediamine and its Lanthanoid (III) complexes against bacterial and fungal isolates, both will not be potential antibacterial agent but Bis-salicylaldehyde ethylenediamine could be pontential antifungal agent. We therefore, recommend further researches geared toward exploring its full potentials for antifungal therapy.
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