埃及肥胖儿童甲状腺激素和一些脂肪细胞因子的评估

Q Medicine Clinical Lipidology Pub Date : 2015-08-01 DOI:10.2217/clp.15.22

A. Ayman, Hebatallah A. Darwish, A. A. Abd El-Maksoud, A. Shaheen

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引用次数: 1

摘要

摘要目的:儿童肥胖是发达国家和越来越多的发展中国家面临的最严重的公共卫生问题之一。在这项研究中，我们旨在探讨甲状腺激素和一些脂肪因子在儿童肥胖中的可能作用。材料与方法:共入组80例儿童;50名肥胖儿童和30名年龄和性别相匹配的非肥胖儿童。监测临床、人口统计学特征和血脂水平。测定血浆中甲状腺激素、瘦素、IL-1α和TNF-α的水平。结果:肥胖儿童血脂异常较正常儿童明显。肥胖儿童的TSH和游离T4水平显著降低。肥胖儿童瘦素和IL-1α水平均升高，而TNF-α水平明显降低。结论:埃及儿童甲状腺激素水平、瘦素、IL-1α和TNF-α的改变与肥胖有关。

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Assessment of thyroid hormones status and some adipocytokines among Egyptian obese children

Abstract Aim: Childhood obesity is one of the most serious public health problems facing the developed and increasingly, the developing world. In this study, we aimed to investigate the possible role of thyroid hormones and some adipokines in childhood obesity. Materials & methods: A total of 80 children were enrolled; 50 obese children and 30 non-obese of matched age and sex. Clinical, demographic characteristics and lipid profile levels were monitored. Plasma levels of thyroid hormones, leptin, IL-1α and TNF-α were measured in these subjects. Results: Dyslipidemia was evident in obese children relative to normal ones. Obese children exhibited a significant reduction in TSH and free- T4 levels. There was an increment in both leptin and IL-1α levels of obese children, however, their TNF-α level were significantly decreased. Conclusion: Alterations in thyroid hormones status, leptin, IL-1α and TNF-α are associated with obesity in Egyptian children.

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来源期刊

Clinical Lipidology 生物-生化与分子生物学

CiteScore

0.44

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Clinical Lipidology is published to support the diverse array of medical professionals who work to reduce the incidence of morbidity and mortality from dyslipidemia and associated disorders of lipid metabolism. The Journal''s readership encompasses a broad cross-section of the medical community, including cardiologists, endocrinologists, and primary care physicians, as well as those involved in the treatment of such disorders as diabetes, hypertension, and obesity. The Journal also addresses allied health professionals who treat the patient base described above, such as pharmacists, nurse practitioners and dietitians. Because the scope of clinical lipidology is broad, the topics addressed by the Journal are equally diverse. Typical articles explore lipidology as it is practiced in the treatment setting, recent developments in pharmacological research, reports of treatment and trials, case studies, the impact of lifestyle modification, and similar academic material of interest to the practitioner. While preference is given to material of immediate practical concern, the science that underpins lipidology is forwarded by expert contributors so that evidence-based approaches to reducing cardiovascular and coronary heart disease can be made immediately available to our readers. Sections of the Journal will address pioneering studies and the clinicians who conduct them, case studies, ethical standards and conduct, professional guidance such as ATP and NCEP, editorial commentary, letters from readers, National Lipid Association (NLA) news and upcoming event information, as well as abstracts from the NLA annual scientific sessions and the scientific forums held by its chapters, when appropriate.