{"title":"胆汁淤积和线粒体功能障碍:综述","authors":"A. Rolo, C. Palmeira","doi":"10.1080/10769180052008878","DOIUrl":null,"url":null,"abstract":"Although liver diseases such as cholestasis are a significant clinical problem, the cellular mechanisms disturbed during these pathophysiological processes are still controversial. Progress along several lines of research have revealed several possible lines of action, pointing to new approaches to medical treatment. Impairment of mitochondrial function seems to be a central biochemical pathway of cell dysfunction during disease. Additionally, perturbation of other cellular functions could play a pivotal role in triggering these pathological events. Our review provides an overview of probable events involved in the cholestatic disease process.","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"CHOLESTASIS AND MITOCHONDRIAL DYSFUNCTION: A REVIEW\",\"authors\":\"A. Rolo, C. Palmeira\",\"doi\":\"10.1080/10769180052008878\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Although liver diseases such as cholestasis are a significant clinical problem, the cellular mechanisms disturbed during these pathophysiological processes are still controversial. Progress along several lines of research have revealed several possible lines of action, pointing to new approaches to medical treatment. Impairment of mitochondrial function seems to be a central biochemical pathway of cell dysfunction during disease. Additionally, perturbation of other cellular functions could play a pivotal role in triggering these pathological events. Our review provides an overview of probable events involved in the cholestatic disease process.\",\"PeriodicalId\":87425,\"journal\":{\"name\":\"Toxic substance mechanisms\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxic substance mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/10769180052008878\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxic substance mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/10769180052008878","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CHOLESTASIS AND MITOCHONDRIAL DYSFUNCTION: A REVIEW
Although liver diseases such as cholestasis are a significant clinical problem, the cellular mechanisms disturbed during these pathophysiological processes are still controversial. Progress along several lines of research have revealed several possible lines of action, pointing to new approaches to medical treatment. Impairment of mitochondrial function seems to be a central biochemical pathway of cell dysfunction during disease. Additionally, perturbation of other cellular functions could play a pivotal role in triggering these pathological events. Our review provides an overview of probable events involved in the cholestatic disease process.