含有植物化学肽衍生物的各种脂质体制剂的稳定性

H. Seok, S. Y. Kim, Lee Kyung Rok, H. Seo, S. Moh
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引用次数: 1

摘要

在本研究中,我们考察了含有植物化学物质-肽衍生物的脂质体制剂的稳定性。在不同条件下用卵磷脂或表面活性剂制备的脂质体中,以棕榈酰肌氨酸钠和夏威夷果籽油制备的脂质体最稳定。TEM图像证实了含肽niosome (N9)的稳定性。经Turbiscan检测,N9在0度和45度处稳定,粒径为95.7 nm。BCA检测结果显示N9的zeta电位值为- 78.19 mV,肽包合率为65.2%。
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Stability of Various Liposome Formulation Containing the Phytochemical-Peptide Derivatives
: In this study, we investigated the stability of the liposome formulation containing the phytochemicals-peptide derivatives. Among liposomes prepared using lecithins or surfactant under various conditions, the most stable niosome was obtained by using sodium palmitoyl sarcosinate and macadamia intergrifolia seed oil. The stability of peptide-con-taining niosome (N9) was confirmed by the TEM images. The N9 was stable at 0 and 45 degrees by Turbiscan, and its particle size was 95.7 nm. The N9 showed zeta potential value of - 78.19 mV, and peptide-inclusion rate of 65.2% by BCA assay.
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