肺神经内分泌肿瘤

A. Burke, Kristen M. Stashek
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摘要

在这篇综述中,我们讨论了肺上皮神经内分泌肿瘤的临床和病理方面,并比较了目前的分类与胃肠道(GI)神经内分泌肿瘤。内分泌肿瘤可分为两大类,目前认为,这两大类不是一个连续体的一部分,而是不同的发病实体。高分化神经内分泌肿瘤(NETs)是一种低级别恶性肿瘤。在肺部,术语“类癌”仍然适用于这些,分为典型或非典型。在胰腺和胃肠道中,根据Ki-67增殖指数将高分化NETs分为3个数字类别。低分化神经内分泌癌(NECs)在器官系统中分为小细胞癌和大细胞癌。在这篇评论中,“。NET”与“区分良好的。NET”可以互换使用。虽然常用于胃肠道,但“低分化NEC”一词并不用于肺,肺中小细胞癌和LCNEC的区别比胃肠道更明确。
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Neuroendocrine Neoplasms of the Lung
In this review, we discuss the clinical and pathologic aspects of epithelial neuroendocrine neoplasms of the lung and compare the current classification with that of gastrointestinal (GI) neuroendocrine neoplasms. Endocrine neoplasms can be broken down into 2 major categories, which, as currently believed, are not part of a continuum, but rather distinct pathogenetic entities. Well-differentiated neuroendocrine tumors (NETs) are low-grade malignancies. In the lung, the term “carcinoid” is still applied for these, which are classified as typical or atypical. In the pancreas and GI tract, well-differentiated NETs are graded based on Ki-67 proliferative index into 3 numeric categories. Poorly differentiated neuroendocrine carcinomas (NECs) are classified in both organ systems into small cell carcinoma and large cell NEC. In this review, “NET” is used interchangeably with “well-differentiated NET.” Although often used in the GI tract, “poorly differentiated NEC” is not a term used in the lung, where the distinction between small cell carcinoma and LCNEC is more clear-cut than in the GI tract.
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期刊介绍: Each issue of Pathology Case Reviews examines one vital theme in the field with peer-reviewed, clinically oriented case reports that focus on diagnosis, specimen handling and reports generation. Each theme-oriented issue covers both histopathologic and cytopathologic cases, offering a comprehensive perspective that includes editorials and review articles of the newest developments in the field, differential diagnosis hints, applications of new technologies, reviews of current issues and techniques and an emphasis on new approaches.
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