Brian Vadasz, K. Wolniak, M. Sukhanova, Yi-Hua Chen, A. Behdad
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Leukemic Presentation of Anaplastic Large Cell Lymphoma: A Diagnostic Challenge Mimicking T-Cell Prolymphocytic Leukemia
Abstract Anaplastic large cell lymphoma (ALCL) is a rare systemic T-cell neoplasm that typically involves nodal and extranodal sites and is further classified into 2 subgroups: anaplastic lymphoma kinase (ALK-) positive (ALK+) and ALK-negative. Leukemic presentation of ALCL is extremely rare. Most cases with leukemic presentation are the small-cell variant of ALK+ ALCL, are positive for the t(2;5)(p23;q35) translocation, and are associated with a poor prognosis. We report a case of ALK+ ALCL that presented with a high white blood cell count and morphologic and phenotypic features resembling T-cell prolymphocytic leukemia.
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