{"title":"利用益生小鼠发现并验证具有治疗活性的微生物群，以维持粘膜稳态和治疗肠道炎症","authors":"R. Balfour Sartor","doi":"10.1016/j.ddmod.2019.08.009","DOIUrl":null,"url":null,"abstract":"<div><p><span>Studies in gnotobiotic mice have dramatically expanded our understanding of the functional importance of </span>microbiota<span> in the pathogenesis of chronic intestinal inflammation. This brief review describes several strategies by which gnotobiotic mice models can be used to efficiently discover and validate protective components from the resident microbiota for potential therapeutic applications. We provide highly targeted examples of studies that use each of the various strategies to illustrate effective approaches, discuss challenges to implementing these approaches and suggest future directions to accelerate this increasingly important line of research and improve the clinical applications of results.</span></p></div>","PeriodicalId":39774,"journal":{"name":"Drug Discovery Today: Disease Models","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.08.009","citationCount":"1","resultStr":"{\"title\":\"Using gnotobiotic mice to discover and validate therapeutically active microbiota to maintain mucosal homeostasis and treat intestinal inflammation\",\"authors\":\"R. Balfour Sartor\",\"doi\":\"10.1016/j.ddmod.2019.08.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Studies in gnotobiotic mice have dramatically expanded our understanding of the functional importance of </span>microbiota<span> in the pathogenesis of chronic intestinal inflammation. This brief review describes several strategies by which gnotobiotic mice models can be used to efficiently discover and validate protective components from the resident microbiota for potential therapeutic applications. We provide highly targeted examples of studies that use each of the various strategies to illustrate effective approaches, discuss challenges to implementing these approaches and suggest future directions to accelerate this increasingly important line of research and improve the clinical applications of results.</span></p></div>\",\"PeriodicalId\":39774,\"journal\":{\"name\":\"Drug Discovery Today: Disease Models\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ddmod.2019.08.009\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today: Disease Models\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1740675719300180\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: Disease Models","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740675719300180","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Using gnotobiotic mice to discover and validate therapeutically active microbiota to maintain mucosal homeostasis and treat intestinal inflammation
Studies in gnotobiotic mice have dramatically expanded our understanding of the functional importance of microbiota in the pathogenesis of chronic intestinal inflammation. This brief review describes several strategies by which gnotobiotic mice models can be used to efficiently discover and validate protective components from the resident microbiota for potential therapeutic applications. We provide highly targeted examples of studies that use each of the various strategies to illustrate effective approaches, discuss challenges to implementing these approaches and suggest future directions to accelerate this increasingly important line of research and improve the clinical applications of results.
期刊介绍：
Drug Discovery Today: Disease Models discusses the non-human experimental models through which inference is drawn regarding the molecular aetiology and pathogenesis of human disease. It provides critical analysis and evaluation of which models can genuinely inform the research community about the direct process of human disease, those which may have value in basic toxicology, and those which are simply designed for effective expression and raw characterisation.
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