纤维素聚合物与糖融合法制备布洛芬固体分散体的溶解谱

Nadia Saffoon, Y. Jhanker, N. Huda
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引用次数: 13

摘要

本研究的目的是制备并表征含HPMC、HPC、冰糖、葡萄糖、甘露醇和乳糖的非甾体抗炎药布洛芬固体分散体,以改善其溶出性能。采用熔合法制备固体分散体。通过溶出度研究对分散体的性能进行了评价。结果表明,与HPMC和HPC配制成固体分散体时,布洛芬的溶出速度明显提高。含有糖粉、葡萄糖、甘露醇和乳糖的固体分散体具有药物缓释能力,利用这一特性制备缓释剂型的研究有待进一步深入。关键词:布洛芬;固体分散;融合方法;溶解率。DOI: http://dx.doi.org/10.3329/sjps.v4i1.8864 SJPS 2011;4 (1): 31-37
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Dissolution Profile of Ibuprofen Solid Dispersion Prepared with Cellulosic Polymers and Sugar by Fusion Method
The purpose of this study was to prepare and characterize solid dispersions of the NSAID Ibuprofen with HPMC, HPC, icing sugar, dextrose, mannitol and lactose with the intention of improving its dissolution properties. The solid dispersions were prepared by the fusion method. Evaluation of the properties of the dispersions was performed using dissolution studies. The results obtained showed that the rate of dissolution of Ibuprofen was considerably improved when formulated in solid dispersions with HPMC and HPC. Solid dispersions with icing sugar, dextrose, mannitol and lactose showed drug retarding capability which may trigger more research in the intension of exploiting this feature to prepare sustained release dosage form. Key words : Ibuprofen; Solid dispersion; Fusion method; Dissolution rate. DOI: http://dx.doi.org/10.3329/sjps.v4i1.8864 SJPS 2011; 4(1): 31-37
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