{"title":"逆转非抗肿瘤蒽环类药物的多药耐药。","authors":"Makoto Inaba, Kyoko Nagashima, Yoshio Sakurai, Masaru Fukui, Yoshikazu Yanagi","doi":"10.20772/CANCERSCI1959.75.12_1049","DOIUrl":null,"url":null,"abstract":"It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.","PeriodicalId":74436,"journal":{"name":"Philosophia (Ramat-Gan, Israel)","volume":"27 1","pages":"1049-52"},"PeriodicalIF":0.0000,"publicationDate":"1984-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"28","resultStr":"{\"title\":\"Reversal of multidrug resistance by non-antitumor anthracycline analogs.\",\"authors\":\"Makoto Inaba, Kyoko Nagashima, Yoshio Sakurai, Masaru Fukui, Yoshikazu Yanagi\",\"doi\":\"10.20772/CANCERSCI1959.75.12_1049\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.\",\"PeriodicalId\":74436,\"journal\":{\"name\":\"Philosophia (Ramat-Gan, Israel)\",\"volume\":\"27 1\",\"pages\":\"1049-52\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1984-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"28\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Philosophia (Ramat-Gan, Israel)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20772/CANCERSCI1959.75.12_1049\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Philosophia (Ramat-Gan, Israel)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20772/CANCERSCI1959.75.12_1049","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Reversal of multidrug resistance by non-antitumor anthracycline analogs.
It was found that three synthetic anthracycline analogs lacking not only antitumor activity but also calcium-antagonizing action possessed an activity to potentiate vincristine cytotoxicity against vincristine-resistant P388 leukemia. ID-8279, one of these analogs, significantly reversed resistance to vincristine and daunorubicin by increasing their intracellular accumulation.
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