肺结核患者血清腺苷脱氨酶水平与微生物参数的相关性

IF 2 4区 地球科学 Q4 CHEMISTRY, PHYSICAL Clays and Clay Minerals Pub Date : 2024-07-01 Epub Date: 2023-02-01 DOI:10.1007/s12291-023-01116-5
Krishna Sarkar, Bineeta Kashyap, Rajat Jhamb, S V Madhu, Rajnish Avasthi, Puneeta Hyanki
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引用次数: 0

摘要

肺结核的准确诊断主要依靠痰涂片显微镜检查、培养和基因Xpert MTB/RIF 检测,其中培养是金标准。所有这些诊断检测都要求痰样结核分枝杆菌呈阳性,而许多活动性肺结核患者的痰中结核分枝杆菌往往并不呈阳性。生化指标在结核病的早期诊断、疾病预防和药物反应中发挥着重要作用。本研究旨在发现血清腺苷脱氨酶(一种生物标记物)与肺结核患者痰涂片镜检、培养和 CBNAAT 等各种微生物指标之间的关联。自2019年11月至2021年10月,共收集了40例经齐氏-奈尔森酸性快速杆菌染色和/或CBNAAT诊断的肺结核推定病例。对血清腺苷脱氨酶水平进行了估计。
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Correlation of serum Adenosine Deaminase levels with microbiological parameters in Pulmonary Tuberculosis.

Accurate diagnosis of pulmonary tuberculosis is largely based on sputum smear microscopy, culture, and GeneXpert MTB/RIF tests; culture being the gold standard. All these diagnostic tests require sputum sample to be positive for Mycobacterium tuberculosis, while many active TB patients often do not present with M. tuberculosis positive sputum. Biochemical markers play an important role in early diagnosis, disease prevention, and drug response in tuberculosis. This study aims to find the association of serum adenosine deaminase (a biomarker) with the various microbiological parameters like sputum smear microscopy, culture and CBNAAT in pulmonary tuberculosis patients. A total of 40 cases were collected from November 2019 to October 2021, and the presumptive cases of pulmonary tuberculosis diagnosed by Ziehl-Neelsen staining for acid fast bacilli and/or CBNAAT were recruited. Serum adenosine deaminase levels were estimated.The following variables were significantly associated (p < 0.05) with serum adenosine deaminase levels: age, sputum smear microscopy findings, time to culture positivity, CBNAAT category and Ct value (Mean).This study does witness few significant correlations between serum adenosine deaminase levels and various microbiological parameters used in diagnosis of TB, which can be further explored and utilised in diagnosis and treatment of pulmonary tuberculosis.

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来源期刊
Clays and Clay Minerals
Clays and Clay Minerals 地学-地球科学综合
CiteScore
3.40
自引率
9.10%
发文量
46
审稿时长
3 months
期刊介绍: Clays and Clay Minerals aims to present the latest advances in research and technology concerning clays and other fine-grained minerals, including but not limited to areas in agronomy, ceramics, colloid chemistry, crystallography, environmental science, foundry engineering, geochemistry, geology, medicinal chemistry, mineralogy, nanoscience, petroleum engineering, physical chemistry, sedimentology, soil mechanics, and soil science. Clays and Clay Minerals exists to disseminate to its worldwide readership the most recent developments in all of these aspects of clay materials. Manuscripts are welcome from all countries.
期刊最新文献
Correlation of serum Adenosine Deaminase levels with microbiological parameters in Pulmonary Tuberculosis. Identifying Detrital and Diagenetic Minerals in Paleosols of the Illinois Basin Characterization Study of some Bauxite Deposits in Northern Brazil Super-efficient Reduction of 4-nitrophenol Using Raw Pelagic Clays as Catalysts Experimental Peloid Formulation Using a Portuguese Bentonite and Different Mineral-Medicinal Waters Suitable for Therapeutic and Well-being Purposes
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