高分子场理论方法研究DNA热变性:环境效应

IF 0.9 4区 物理与天体物理 Q4 PHYSICS, CONDENSED MATTER Condensed Matter Physics Pub Date : 2021-07-25 DOI:10.5488/CMP.24.33603
Y. Holovatch, C. von Ferber, Y. Honchar
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引用次数: 0

摘要

我们分析了环境的影响(溶剂质量,扩展结构的存在-拥挤的环境),这些影响可能会影响变性和有界DNA状态之间的过渡顺序,并导致控制DNA链构象性质的缩放定律的变化。我们发现所研究的效应显著地影响了一阶跃迁的强度。为此,我们重新考虑了波兰-谢拉加模型,并应用聚合物场理论来计算与变性环分布相关的熵指数。对于d = 3情况,通过恢复技术恢复ε = 4-d展开式的收敛性,从而求得相应的发散展开式。对于空间维度d = 2,指数是通过将聚合物模型映射到二维随机晶格,即在量子引力存在的情况下推导出来的。我们还表明,一阶跃迁进一步加强了溶剂中扩展的不可穿透区域的存在,这限制了大分子构型的数量。
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DNA thermal denaturation by polymer field theory approach: effects of the environment
We analyse the effects of the environment (solvent quality, presence of extended structures - crowded environment) that may have impact on the order of the transition between denaturated and bounded DNA states and lead to changes in the scaling laws that govern conformational properties of DNA strands. We find that the effects studied significantly influence the strength of the first order transition. To this end, we re-consider the Poland-Scheraga model and apply a polymer field theory to calculate entropic exponents associated with the denaturated loop distribution. For the d = 3 case, the corresponding diverging ε = 4-d expansions are evaluated by restoring their convergence via the resummation technique. For the space dimension d = 2, the exponents are deduced from mapping the polymer model onto a two-dimensional random lattice, i.e., in the presence of quantum gravity. We also show that the first order transition is further strengthened by the presence of extended impenetrable regions in a solvent that restrict the number of the macromolecule configurations.
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来源期刊
Condensed Matter Physics
Condensed Matter Physics 物理-物理:凝聚态物理
CiteScore
1.10
自引率
16.70%
发文量
17
审稿时长
1 months
期刊介绍: Condensed Matter Physics contains original and review articles in the field of statistical mechanics and thermodynamics of equilibrium and nonequilibrium processes, relativistic mechanics of interacting particle systems.The main attention is paid to physics of solid, liquid and amorphous systems, phase equilibria and phase transitions, thermal, structural, electric, magnetic and optical properties of condensed matter. Condensed Matter Physics is published quarterly.
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