Structure-based drug design

Volume 1 • Issue 4 • 1000e111 J Pharmacovigilance ISSN: 2329-6887 JP, an open access journal In today’s world where life is fast-paced, public health is a big concern. With the tremendous ongoing development in the field of pharmaceutical drugs, people can find cure for a vast variety of diseases. These modern-day medicines have been proven to be more effective in treating, managing, controlling and preventing the diseases and their reoccurrence. For example, cancer patients, who had a very low rate of survival in 1970’s, can now be treated more efficiently by chemotherapy. At present, the cancer death rate has declined by 20% in comparison to 1990 [1]. However, along with rapid progress in the efficacy of these pharmaceutical medicines, have come long-term undesirable side effects, poor absorption and clearance, multi-drug resistance, excessive toxicities, and adverse reactions of these medicines. Hence, there is a stringent need to get a closer insight into these drugs in terms of their structure and function, their molecular interactions with large biomolecules (protein, nucleic acids) within the cell, so as to design and/or modify the drugs to have improved potency, fewer side effects and selective binding to their biomolecular target.