羊水缺血修饰白蛋白作为唐氏综合征新的产前诊断标志物:一项前瞻性病例对照研究

IF 0.1 Q4 OBSTETRICS & GYNECOLOGY Journal of Clinical Obstetrics and Gynecology Pub Date : 2023-06-21 DOI:10.29328/journal.cjog.1001133
Guven Suleyman, Comert Erhan Huseyin, Guven Emine Seda Guvendag, Demir Bulent, Karcaaltincaba Deniz
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引用次数: 0

摘要

目的:尚没有文献报道唐氏综合征患者羊水中缺血修饰白蛋白(IMA)和肝细胞生长因子(HGF)水平的变化。本研究的目的是研究与正常胎儿相比,唐氏综合征患者在妊娠16-20周时IMA和HGF的变化。方法:本前瞻性病例对照研究,在产前诊断为唐氏综合征的妇女达到20名(研究组)后,从储存的羊水样本中选择母体与胎龄匹配的正常体质核型孕妇(n = 74)作为对照组。结果:两组的平均妇女和胎龄具有可比性。羊水IMA(1.32±0.13比1.11±0.11 ABSU, p < 0.001)和HGF(2743.53±1389.28比2160.12±654.63 pg/mL, p = 0.008)。与正常胎儿的孕妇相比,患有唐氏综合症胎儿的孕妇的水平明显更高。羊水IMA水平诊断唐氏综合征的敏感性和特异性分别为95.0%和71.6%,极限值为1.171 cm3。结论:在疑似唐氏综合征的病例中,通过测定胎儿核型羊水样本中的IMA水平,可在约1小时内做出唐氏综合征的诊断,具有较高的敏感性和特异性。
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Amniotic Fluid Ischemia Modified Albumin as a Novel Prenatal Diagnostic Marker for Down Syndrome: A Prospective Case-Control Study
Aims: There is no study in the literature about ischemia-modified albumin (IMA) and hepatocyte growth factor (HGF) levels in amniotic fluid for Down syndrome cases. The aim of this study was to investigate the changes of IMA and HGF in Down syndrome cases at 16-20 weeks of gestation compared to normal fetuses. Methods: For this prospective case-control study, following reaching the number of 20 women (study group) who had the prenatal diagnosis of Down syndrome, maternal and gestational age-matched pregnant women with normal constitutional karyotype were selected for the control group (n = 74) from the stored amniotic fluid samples. Results: Mean women and gestational ages were comparable between the two groups. Amniotic fluid IMA (1.32 ± 0.13 vs. 1.11 ± 0.11 ABSU, respectively, p < 0.001) and HGF (2743.53 ± 1389.28 vs. 2160.12 ± 654.63 pg/mL, respectively, p = 0.008). Levels were significantly higher in pregnant women having Down syndrome fetuses compared with women having normal fetuses. The amniotic fluid IMA levels for the diagnosis of Down syndrome, and the sensitivity and specificity were calculated as 95.0% and 71.6% for the limit value 1.171 cm3, respectively. Conclusion: In cases with suspected Down syndrome, the diagnosis of Down Syndrome may be made in approximately 1 hour with high sensitivity and specificity by measuring the IMA level in the amniotic fluid sample taken for fetal karyotyping.
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来源期刊
Journal of Clinical Obstetrics and Gynecology
Journal of Clinical Obstetrics and Gynecology Medicine-Obstetrics and Gynecology
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8
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