人类精子中Hv1的翻译后裂解调节pH和电压依赖性门控

Thomas K Berger, David M. Fußhöller, Normann Goodwin, W. Bönigk, A. Müller, Nasim Dokani Khesroshahi, C. Brenker, D. Wachten, E. Krause, U. Kaupp, T. Strünker
{"title":"人类精子中Hv1的翻译后裂解调节pH和电压依赖性门控","authors":"Thomas K Berger, David M. Fußhöller, Normann Goodwin, W. Bönigk, A. Müller, Nasim Dokani Khesroshahi, C. Brenker, D. Wachten, E. Krause, U. Kaupp, T. Strünker","doi":"10.1113/JP273189","DOIUrl":null,"url":null,"abstract":"In human sperm, proton flux across the membrane is controlled by the voltage‐gated proton channel Hv1. We show that sperm harbour both Hv1 and an N‐terminally cleaved isoform termed Hv1Sper. The pH‐control of Hv1Sper and Hv1 is distinctively different. Hv1Sper and Hv1 can form heterodimers that combine features of both constituents. Cleavage and heterodimerization of Hv1 might represent an adaptation to the specific requirements of pH control in sperm.","PeriodicalId":22512,"journal":{"name":"The Japanese journal of physiology","volume":"64 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"43","resultStr":"{\"title\":\"Post‐translational cleavage of Hv1 in human sperm tunes pH‐ and voltage‐dependent gating\",\"authors\":\"Thomas K Berger, David M. Fußhöller, Normann Goodwin, W. Bönigk, A. Müller, Nasim Dokani Khesroshahi, C. Brenker, D. Wachten, E. Krause, U. Kaupp, T. Strünker\",\"doi\":\"10.1113/JP273189\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In human sperm, proton flux across the membrane is controlled by the voltage‐gated proton channel Hv1. We show that sperm harbour both Hv1 and an N‐terminally cleaved isoform termed Hv1Sper. The pH‐control of Hv1Sper and Hv1 is distinctively different. Hv1Sper and Hv1 can form heterodimers that combine features of both constituents. Cleavage and heterodimerization of Hv1 might represent an adaptation to the specific requirements of pH control in sperm.\",\"PeriodicalId\":22512,\"journal\":{\"name\":\"The Japanese journal of physiology\",\"volume\":\"64 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"43\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Japanese journal of physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1113/JP273189\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Japanese journal of physiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1113/JP273189","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 43

摘要

在人类精子中,质子通过膜的通量是由电压门控质子通道Hv1控制的。我们发现精子同时含有Hv1和一种被称为Hv1Sper的N端分裂异构体。Hv1Sper和Hv1的pH控制明显不同。Hv1Sper和Hv1可以形成结合两种成分特征的异源二聚体。Hv1的分裂和异源二聚化可能代表了对精子pH控制的特殊要求的适应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Post‐translational cleavage of Hv1 in human sperm tunes pH‐ and voltage‐dependent gating
In human sperm, proton flux across the membrane is controlled by the voltage‐gated proton channel Hv1. We show that sperm harbour both Hv1 and an N‐terminally cleaved isoform termed Hv1Sper. The pH‐control of Hv1Sper and Hv1 is distinctively different. Hv1Sper and Hv1 can form heterodimers that combine features of both constituents. Cleavage and heterodimerization of Hv1 might represent an adaptation to the specific requirements of pH control in sperm.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
The substantia nigra modulates proximal colon tone and motility in a vagally-dependent manner in the rat. Mechanisms of Hebbian‐like plasticity in the ventral premotor – primary motor network Maternal obesity: influencing the heart right from the start Motor unit dysregulation following 15 days of unilateral lower limb immobilisation Back to the beginning: can we stop brain injury before it starts?
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1