跨越脑-体轴的广泛自主生理耦合。

IF 0.9 4区 材料科学 Q3 CRYSTALLOGRAPHY Zeitschrift Fur Kristallographie-Crystalline Materials Pub Date : 2024-07-29 DOI:10.1101/2023.01.19.524818
Taylor Bolt, Shiyu Wang, Jason S Nomi, Roni Setton, Benjamin P Gold, Blaise deB Frederick, B T Thomas Yeo, J Jean Chen, Dante Picchioni, R Nathan Spreng, Shella D Keilholz, Lucina Q Uddin, Catie Chang
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引用次数: 0

摘要

大脑与来自身体内部环境的内脏信号密切相关,这从神经、血液动力学和外周生理信号之间的众多关联中可见一斑。我们的研究表明,这些脑-体共同波动可以通过单一时空模式捕捉到。在多个独立样本以及单回波和多回波 fMRI 数据采集序列中,我们确定了静息态全局 fMRI 信号、神经活动和一系列横跨心血管、肺、外分泌和平滑肌系统的自律神经信号之间在低频范围(0.01 - 0.1 Hz)内的广泛共同波动。在静息状态下观察到的同样的脑-体共同波动也会被诱导深呼吸和间歇性感官刺激引起的唤醒以及睡眠期间自发的相位脑电图事件所激发。此外,我们还发现,在实验性抑制潮气末二氧化碳(PETCO2)变化的情况下,全局 fMRI 信号的空间结构仍然保持不变,这表明呼吸驱动的伴随唤醒的动脉二氧化碳波动无法解释这些信号在大脑中的起源。这些发现确立了全局 fMRI 信号是自律神经系统支配的唤醒反应的重要组成部分。
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Widespread Autonomic Physiological Coupling Across the Brain-Body Axis.

The brain is closely attuned to visceral signals from the body's internal environment, as evidenced by the numerous associations between neural, hemodynamic, and peripheral physiological signals. We show that these brain-body co-fluctuations can be captured by a single spatiotemporal pattern. Across several independent samples, as well as single-echo and multi-echo fMRI data acquisition sequences, we identify widespread co-fluctuations in the low-frequency range (0.01 - 0.1 Hz) between resting-state global fMRI signals, neural activity, and a host of autonomic signals spanning cardiovascular, pulmonary, exocrine and smooth muscle systems. The same brain-body co-fluctuations observed at rest are elicited by arousal induced by cued deep breathing and intermittent sensory stimuli, as well as spontaneous phasic EEG events during sleep. Further, we show that the spatial structure of global fMRI signals is maintained under experimental suppression of end-tidal carbon dioxide (PETCO2) variations, suggesting that respiratory-driven fluctuations in arterial CO2 accompanying arousal cannot explain the origin of these signals in the brain. These findings establish the global fMRI signal as a significant component of the arousal response governed by the autonomic nervous system.

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来源期刊
CiteScore
2.00
自引率
16.70%
发文量
55
期刊介绍: Zeitschrift für Kristallographie – Crystalline Materials was founded in 1877 by Paul von Groth and is today one of the world’s oldest scientific journals. It offers a place for researchers to present results of their theoretical experimental crystallographic studies. The journal presents significant results on structures and on properties of organic/inorganic substances with crystalline character, periodically ordered, modulated or quasicrystalline on static and dynamic phenomena applying the various methods of diffraction, spectroscopy and microscopy.
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