R. Rutkowski, K. Rutkowski, Joanna Rutkowska-Talipska, P. Sowa, S. Sułkowski
{"title":"维生素C:是时候重新评估它在健康和疾病中的作用了吗?","authors":"R. Rutkowski, K. Rutkowski, Joanna Rutkowska-Talipska, P. Sowa, S. Sułkowski","doi":"10.5114/PDIA.2012.32394","DOIUrl":null,"url":null,"abstract":"A b s t r a c t Vitamin C (VC; ascorbic acid, AA) is synthesised from glucose in the liver of most mammals, but not in humans. Syn thetic AA supplementation is often necessary to prevent vitamin C deficiency. Intracellularly AA is reversibly oxidized to an ascorbic radical which converts into dehydroascorbic acid (DHA). Ascorbic acid crosses cell membranes with SVCT1, SVCT2 or GLUT1, GLUT3 and GLUT4 transporters. Recommended daily allowance for VC is around 75 mg/day for women and 90 mg/day for men. This seems to be too low in relation to real human body needs and does not ensure true health protection. There are ongoing studies re-evaluating the role of VC in cancer treatment. There fore, it would be also appropriate to reassess its use as a specific drug in the prevention and therapy of asthma, aller gic rhinitis and atopic dermatitis.","PeriodicalId":7212,"journal":{"name":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","volume":"56 1","pages":"456-460"},"PeriodicalIF":0.0000,"publicationDate":"2012-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Review paper Vitamin C: is it time to re-evaluate its role in health and disease?\",\"authors\":\"R. Rutkowski, K. Rutkowski, Joanna Rutkowska-Talipska, P. Sowa, S. Sułkowski\",\"doi\":\"10.5114/PDIA.2012.32394\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A b s t r a c t Vitamin C (VC; ascorbic acid, AA) is synthesised from glucose in the liver of most mammals, but not in humans. Syn thetic AA supplementation is often necessary to prevent vitamin C deficiency. Intracellularly AA is reversibly oxidized to an ascorbic radical which converts into dehydroascorbic acid (DHA). Ascorbic acid crosses cell membranes with SVCT1, SVCT2 or GLUT1, GLUT3 and GLUT4 transporters. Recommended daily allowance for VC is around 75 mg/day for women and 90 mg/day for men. This seems to be too low in relation to real human body needs and does not ensure true health protection. There are ongoing studies re-evaluating the role of VC in cancer treatment. There fore, it would be also appropriate to reassess its use as a specific drug in the prevention and therapy of asthma, aller gic rhinitis and atopic dermatitis.\",\"PeriodicalId\":7212,\"journal\":{\"name\":\"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii\",\"volume\":\"56 1\",\"pages\":\"456-460\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2012-12-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/PDIA.2012.32394\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/PDIA.2012.32394","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Review paper Vitamin C: is it time to re-evaluate its role in health and disease?
A b s t r a c t Vitamin C (VC; ascorbic acid, AA) is synthesised from glucose in the liver of most mammals, but not in humans. Syn thetic AA supplementation is often necessary to prevent vitamin C deficiency. Intracellularly AA is reversibly oxidized to an ascorbic radical which converts into dehydroascorbic acid (DHA). Ascorbic acid crosses cell membranes with SVCT1, SVCT2 or GLUT1, GLUT3 and GLUT4 transporters. Recommended daily allowance for VC is around 75 mg/day for women and 90 mg/day for men. This seems to be too low in relation to real human body needs and does not ensure true health protection. There are ongoing studies re-evaluating the role of VC in cancer treatment. There fore, it would be also appropriate to reassess its use as a specific drug in the prevention and therapy of asthma, aller gic rhinitis and atopic dermatitis.
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