{"title":"在健康志愿者中,短暂的交流减少了西咪替丁后扑热息痛的吸收","authors":"M. Garba, A. Mustapha, M. Bakare, I. Aguye","doi":"10.1080/107691897229586","DOIUrl":null,"url":null,"abstract":"Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p < .001 for the max difference between the two cases-control and treated). Lag time was greatly increased ( p <.001). This indicates that the therapeutic efficacy of paracetamol may be affected.","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"A Brief Communication REDUCED ABSORPTION OF PARACETAMOL FOLLOWING CIMETIDINE IN HEALTHY VOLUNTEERS\",\"authors\":\"M. Garba, A. Mustapha, M. Bakare, I. Aguye\",\"doi\":\"10.1080/107691897229586\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p < .001 for the max difference between the two cases-control and treated). Lag time was greatly increased ( p <.001). This indicates that the therapeutic efficacy of paracetamol may be affected.\",\"PeriodicalId\":87425,\"journal\":{\"name\":\"Toxic substance mechanisms\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxic substance mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/107691897229586\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxic substance mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/107691897229586","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Brief Communication REDUCED ABSORPTION OF PARACETAMOL FOLLOWING CIMETIDINE IN HEALTHY VOLUNTEERS
Cimetidine has not been shown to affect the pharmacokinetics of paracetamol. However, when the protocol was modified in such a way that paracetamol was taken 1 h after cimetidine, there was a significant effect on its absorption. The C and K (absorption constant) were significantly reduced ( p < .001 for the max difference between the two cases-control and treated). Lag time was greatly increased ( p <.001). This indicates that the therapeutic efficacy of paracetamol may be affected.