美沙拉嗪假过敏是治疗升级的原因

M. Calafat , N. Depreux , M. Mañosa , E. Cabré , L. Zacarías , E. Domènech
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引用次数: 1

摘要

美沙拉嗪是轻度至中度溃疡性结肠炎患者的首选药物,用于诱导临床缓解和维持治疗。事实上,有一半的患者只在进展过程中使用美沙拉嗪进行控制。总的来说,它被认为是一种安全的药物,几乎没有副作用。尽管如此,一些对特殊性质的氨基水杨酸盐过敏的病例已经被描述,这可能导致药物的停药。这可能会明显限制治疗管理的机会,特别是在轻度或中度活动的患者或仅累及直肠的患者。我们提出2例溃疡性直肠炎,其中对美沙拉嗪过敏被怀疑,导致疾病控制不足。在完成免疫过敏研究后,排除了敏感性,重新引入药物并实现了快速和长期的临床缓解。
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Falsa hipersensibilidad a mesalazina como causa de escalamiento terapéutico

Mesalazine is the drug of choice in patients with mild-moderate forms of ulcerative colitis, both for inducing clinical remission and for maintenance. In fact, half of patients will be controlled with mesalazine only during their progress. It is overall considered a safe drug, with few adverse effects. Still, some cases of hypersensitivity to aminosalicylates of idiosyncratic nature have been described, which could lead to the withdrawal of the drug. This could notably limit the chances of therapeutic management, especially in patients with a mild or moderate activity or in those with exclusively rectal involvement. We present 2 cases of ulcerative proctitis where an allergy to mesalazine was suspected, what led to an inadequate control of the disease. Upon completion of the immunoallergic study the sensitivity was ruled out, the drug was reintroduced and fast and prolonged clinical remission was achieved.

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