黑曲霉(−)-α-三冬氨酸的微生物羟基化作用

Journal of Fermentation Technology Pub Date : 1988-01-01 DOI:10.1016/0385-6380(88)90129-X

Mitsugi Iida , Akiko Mikami , Koji Yamakawa , Kiyoshi Nishitani

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引用次数: 9

摘要

利用黑曲霉MIL 5024和MIL 5025对倍半萜内酯(−)-α-三冬氨酸进行了微生物转化。菌株MIL 5024将(−)-α-三冬氨酸(400 mg)转化为11-羟基-(−)-α-三冬氨酸(P1) (50.4 mg)、3,6,9-三羟基-9,10-seco-selina-1,3,5(10)-三烯-12-酸-12,6-内酯(P2) (22.4 mg)和3,6-二羟基-9,10-二烯-1,3,5(10)-三烯-9,12-二烯酸-12,6-内酯(P3) (27.1 mg)，并通过紫外、红外、质谱和1H-NMR分析对其进行了分离和表征。所有这些产品都是第一次被描述。另一株菌株MIL 5025转化(−)-α-三antonin也获得了与MIL 5024相似的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microbial Hydroxylation of (−)-α-Santonin by Aspergillus niger

The microbiological transformation of a sesquiterpene lactone, (−)-α-santonin was carried out by using Aspergillus niger MIL 5024 and MIL 5025. Strain MIL 5024 brings about the transformation of (−)-α-santonin (400 mg) to 11-hydroxy-(−)-α-santonin (P1) (50.4 mg), 3,6,9-trihydroxy-9,10-seco-selina-1,3,5(10)-trien-12-oic acid-12,6-lactone (P2) (22.4 mg), and 3,6-dihydroxy-9,10-seco-selina-1,3,5(10)-trien-9,12-dioic acid-12,6-lactone (P3) (27.1 mg), which were isolated and characterized by UV, IR, mass and ¹H-NMR spectroanalyses. All of these products are described for the first time. Results similar to those with MIL 5024 were also obtained from the transformation of (−)-α-santonin by the other isolate, strain MIL 5025.

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