没食子酸腙:硫氧还蛋白还原酶的“硅”抑制

Jovica Branković, V. Milovanović, Z. Petrović, V. Petrović
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引用次数: 0

摘要

没食子腙作为没食子酸衍生物,是许多多能药物的药效团。其中,抗增殖活性是最重要的活性之一。另一方面,硫氧还蛋白还原酶(TrxR1)是硫氧还蛋白系统的一部分,是维持细胞内氧化还原平衡的最重要系统之一。它在不同形式的肿瘤中过度表达。考虑到这一点,TrxR1是开发具有潜在抗增殖活性化合物的有效靶标。为此,我们选择了8个没食子酸基腙,并对它们对TrxR1的潜在抑制活性进行了硅检测。
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GALLIC ACID HYDRAZONES: ‘IN SILICO’ INHIBITION OF THIOREDOXIN REDUCTASE
Gallic hydrazones, as gallic acid derivatives, are known as pharmacophores of numerous multipotent agents. Among them, antiproliferative activity is one of the most important. On the other hand, thioredoxin reductase (TrxR1) is a part of the thioredoxin system, one of the most important systems responsible for maintaining the redox equilibrium inside the cell. It is overexpressed in different forms of tumors. Bearing this in mind, TrxR1 is a valid target for the development of compounds with potential antiproliferative activity. For this purpose, eight gallic acid-based hydrazones are selected and examined in silico for their potential inhibitory activity towards TrxR1.
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