The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution

Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.