产自委内瑞拉mÉrida的姜黄根茎中姜黄素的提取与表征

Jeans W. Ramírez, M. Guillén, G. Delgado
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引用次数: 0

摘要

天然化合物的提取是发展最快的行业之一,因为它比人工合成的类似物更有优势。环境保护必须要求使用天然产品而不是化学品,以尽量减少污染。因此,本研究研究了一些天然产物,如姜黄素,作为天然存在的酸碱指标的使用。姜黄素具有ph依赖性的溶解度,可作为酸碱指示剂。姜黄素是姜黄(姜黄科)的主要活性成分,在咖喱中用作香料,在黄芥末、化妆品、药品和染发剂中用作着色剂。本研究以种植于委内瑞拉m里达的姜黄(Curcuma longa)为原料,采用索氏萃取系统,以有机溶剂(己烷和乙醇)为萃取溶剂,萃取8 h,得率为3.42%,提取了姜黄素(C21H20O6) (1E,6E)-1,7-二(4-羟基-3-甲氧基苯基)-1,6-庚二烯-3,5-二酮。薄层色谱和色谱柱使用流动相(氯仿-己烷3:2的混合物)进行分离和纯化。该染料通过可见紫外(UV-Vis)和红外(IR)光谱分析进行了表征,此外他的工作室还将其灵敏度作为酸碱指示剂。这种染料在强酸-强碱体积中作为酸碱指示剂是有用的,并且不需要大量的它,因为它具有高灵敏度。结果表明,姜黄素作为一种酸碱指示剂,可以在不同的化学领域建立新的标准。
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EXTRACTION AND CHARACTERIZATION OF CURCUMIN FROM TURMERIC RHIZOMES GROWN IN MÉRIDA, VENEZUELA
The extraction of naturally occurring compounds is one of the fastest-growing industries because of its benefits against its synthetic analogs. Environmental protection must require the use of natural products instead of chemicals to minimize pollution. Thus, this investigation studies the use of some natural product, as curcumin, as naturally occurring acid‐base indicators. Curcumin can be used as acid-base indicators since it was found that it possesses pH-dependent solubility. Curcumin, the major active component of turmeric, Curcuma longa (Zingiberaceae), is used as a spice in curry and as a coloring agent in yellow mustards, cosmetics, pharmaceuticals, and hair dyes. In this research, the main compound colored rhizome of turmeric (Curcuma longa) cultivated in Mérida, Venezuela, is extracted: Curcumin (C21H20O6) (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, in a yield of 3.42% after 8 hours of extraction using soxhlet extractor system with organic solvents (hexane and ethanol). The thin-layer chromatography and column performed separation and purification using a mobile phase, a mixture of chloroform-hexane 3:2. The dye was characterized by spectroscopic analysis of visible ultraviolet (UV-Vis) and infrared (IR), in addition to his studio in steering sensitivity as an acid-base indicator. This dye is useful as an acid-base indicator in strong acid-strong base volumes and did not require large amounts of it as it has high sensitivity. The results indicate that curcumin as an acid-base indicator allows the development of new standards in different chemistry fields that require this type of analysis.
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